Principal Scientist, Adme/Pk

About Us

Valo Health is a technology company that is integrating human-centric data and AI-powered technology to accelerate the creation of life-changing drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive, with a much higher probability of success. We are using models early to fail less often, executing clinical trials to add valuation to the company, and generating fit-for-purpose data to feed back into Valo's Opal Computational Platform as we reinvent drug discovery and development from the ground up. Disease doesn't wait, so neither can we.

We are a multi-disciplinary team of experts in science, technology, and pharmaceuticals united in our mission to achieve better drugs for patients faster. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We achieve the widest-ranging impact when we leverage our broad backgrounds and perspectives to accelerate a new frontier in health. Valo seeks to become the catalyst for the pharmaceutical industry and drive the digital transformation of the industry. Are you ready to join us?

About The Role

Principal Scientist, ADME/PK will play a pivotal role in the Analytical Sciences group managing the day-to-day ADME lab operations and supporting Valo's internal small molecule drug discovery programs focused on cardiovascular indications. Provide domain expertise representation to guide the multidisciplinary project teams and interpretation of ADME/PK results to propose/action next experimental steps. The position will require supervision of junior scientists' work and a hands-on approach to managing assay schedules that provide the most pertinent ADME results in a cycle time that enables rapid evaluation of chemistry SAR. Oversee new technology initiatives and ADMET capabilities to support the needs of the growing portfolio and maintain high levels of data integrity.

What You'll Do…

• Work closely with a team of experienced drug hunters to create novel, differentiated drug candidates, by providing strategic guidance and execution associated with in vitro and in vivo profiling.

• Manage Valo's internal high throughput & definitive ADME assay platform to support the small molecule preclinical pipeline (i.e., metabolic stability, drug permeability, drug-drug interaction, protein binding & solubility studies).

• Identify, qualify, engage, and manage external providers of in vitro ADME and in vivo PK services; analyze and interpret resulting data.

• Supervise and close mentorship/training of junior colleagues in the Analytical Sciences team.

• Oversee day-to-day operation and maintenance of analytical technologies including tandem mass spec instrumentational and liquid handling automation.

• Take the lead in establishing the best experimental ADME workflow practices to maintain a high level of data integrity and traceability.\

• Implementation of new emerging technologies/innovations/assays to advance discovery capabilities and operational efficiencies.

• Partner closely with a team of AI/ML and data scientists to develop and implement a comprehensive and robust platform for in silico prediction of complex ADME/PK properties.

• Recruit and train a versatile team to support growing portfolio needs.

What You Will Bring...

• Broad ADME experience and expertise spanning target assessment to later stage drug development, with an awareness of regulatory guidance and industry trends.

• Well versed in the contemporary application of ADME assay automation, comprehensive workflow integration and data practices with LIMS/ELN software platforms.

• Extensive hands-on experience in the design, qualification, and implementation of novel ADMET and physicochemical assays.

• Leading-edge mindset in relation to current experimental and computational ADME/PK approaches and techniques. Modeling and simulation expertise a plus (PBPK and QSP)

• Ability to effectively communicate and influence in a dynamic and matrixed environment.

• High-performing team mentality, able to lead, follow, and contribute based on the needs of the team and situation.

• Success building and managing ADME-related specialties, with a continuous improvement mindset. Previous experience building and managing an ADME lab-based team a plus.

• Ph.D. in a relevant scientific discipline and 8+ years of drug discovery experience or BS/MS and 15+ years

More on Valo

Valo Health, Inc ("Valo") is a technology company built to transform the drug discovery and development process using human-centric data and artificial intelligence-driven computation. As a digitally native company, Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company's Opal Computational Platform is an integrated set of capabilities designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs across cardiovascular metabolic renal, oncology, and neurodegenerative disease. Founded by Flagship Pioneering and headquartered in Lexington, MA, Valo also has an office in New York. To learn more, visit www.valohealth.com.