Principal Research Associate/Associate Scientist, Cell Biology

Principal Research Associate/Associate Scientist, Cell Biology

About Magnet Biomedicine

Magnet Biomedicine is a fast-paced, collaborative, venture-backed startup developing rational approaches to molecular glue discovery. Magnet's TrueGlueTM Discovery Platform enables the discovery and development of fit-for-purpose molecular glue strategies to target a diverse array of target classes. Our mission is to generate novel protein-protein interactions to modulate target functions, thereby revolutionizing the field of targeted therapeutics and drug discovery. We are seeking a highly motivated and experienced, full-time BS/MS level cell and molecular biologist to join our dynamic team, based out of 321 Harrison Ave, Boston, MA. We offer a competitive compensation package as well as comprehensive benefits.

Job description

Principal Research Associate/Associate Scientist, Cell Biology

As a Principal Research Associate/Associate Scientist on the biology team at Magnet Biomedicine, you will play a pivotal role in designing, executing, and interpreting experiments to develop assays for modulating protein-protein interactions using small molecules. This position offers a unique opportunity to contribute to the development of Magnet's next-generation TrueGlue therapies. You will conduct phenotypic cell-based assays, enzymatic assays, binding experiments, in addition to biochemical and cellular screens. You will collaborate with a team of passionate scientists to discover and develop molecular glue therapeutics.

Key Responsibilities

• Plan and execute cellular and biochemical assays (enzyme activity assays, growth and viability assays, HTRF, etc.).

• Perform and contribute to multi-plexed HTS screening assays.

• Lead CRISPR-Cas9 perturbations and downstream analysis.

• Evaluate protein-protein interactions through NanoBiT, IP-MS, ALPHAscreen, etc.

• Large scale proteomic sample preparation

• Perform cell line engineering and QC.

• Reporter and phenotypic assay development and implementation.

• Maintain impeccable experimental records in an ELN.

• Independently identify and solve technical experimental problems.

• Collaborate closely with all members of the Magnet team.

• Other duties, as assigned.

Required qualifications and skills

• Bachelors or Masters degree in biology or related discipline and 3-5+ years experience in a biotech or pharmaceutical setting

• Experience in human cell culture techniques for diverse cell types, including cell line engineering and QC

• Expertise in cellular and molecular biology, including reporter systems and phenotypic assays

• Ability to perform meticulous experimental planning, execution, and analysis

• Strong analytical mindset and knowledge of relevant statistical methods

• Intellectual curiosity and a positive, collegial attitude

• Expertise with lentiviral packaging and transduction to generate engineered cell systems

• Ability to work at scale in 384-well format; handle/expand cells for HTS and follow-up experiments

• Experience in oncology and/or immunology, with a basic understanding of the human genetics in those areas and target dependency

• Hands-on experience with small-molecule binding/inhibition assays

Preferred qualifications

• Experience with B and T cell models

• Experience with molecular glue therapies or bifunctional molecules

• Proficiency in confocal and fluorescent microscopy

• Working knowledge of DNA-encoded library screening

• Setup and execution of proteomic workflows and sample prep

• Experience with HTRF, AlphaLISA, and bioluminescence assays

• Propagation of primary cells

• Background in protein biochemistry

• Please apply at careers@magnetbio.com