Postdoctoral Researcher

Ohsu Portland , OR 97228

Posted 2 weeks ago

Department Overview

Our laboratory is interest in identifying the metabolic reprograming that occurs during cancer treatment, and how this modifies response. Importantly, we seek to identify metabolic vulnerabilities that occur under selective pressure of treatment, which can then be exploited to eliminate tumor cells. Previous publications from our group include: Genes & Development 20, 2067-2084; Metabolites 5, 82; Cell 174: 758-769; Nature Medicine 12,122-127; Cancer Journal 15, 406-420; Science Translational Medicine 3(85): 85ra47; J Clin Oncol 36: 2492-2503.

Function/Duties of Position

A postdoctoral position is available for an experienced and highly motivated candidate with a background in molecular/cellular biology and/or genetics to join our NIH-funded research group. Evaluation of cancer metabolism, gene function and key signaling events will include the use of in vitro assays, and mouse models; however, special emphasis will be placed on increasing the relevance of experimental findings to human cancer by validating potential therapeutic targets using primary patient samples (e.g. organoids, patient-derived explants) and in vivo xenograft models.

The successful applicant will be responsible for performing experiments in the laboratory which will include DNA, RNA, Protein, Metabolite extraction, Western blotting, Q-Real Time PCR, Tissue culture, Transfections, Functional Metabolomics, Flow Cytometry, Imaging, etc. as well carry out data analysis resulting from experiments and help with manuscript preparation/writing. Analytical expertise in Excel, Graph Pad Prism, Calcusyn is required, and some Bioinformatic experience (R, Python) is an advantage. Position requires strong attention to detail, multi-tasking, working as part of a team and willingness to learn new technologies.

Performs cell culture including drug treatments (40%)Performs basic molecular biology techniques including transfections PCR, Q-PCR, bacterial cloning, DNA/RNA extraction, Western blots, metabolism studies, flow cytometry, etc. (30%)Data analysis using bioinformatics software (10%)Assists in the development of new assays in clinical samples, e.g. organoids, single cell analysis (10%)Additional duties as assigned by principal investigator (10%)

Required Qualifications

A PhD degree in Cell Biology/ Molecular Biology/Genetics

In addition:

  • Highly motivated and committed to academic biomedical research

  • Ability to prioritize multiple tasks at one time

  • Must have excellent communication, analytical and organizational skills: both written and verbal.

  • Ability to work independently and as part of a team while being collaborative in resolving problems.

  • Must be proficient with computers running Windows and PC applications e.g. MS Excel, Oracle, Access, Word and PowerPoint). Typing 60wpm

  • Must have demonstrated excellent customer service skills both on the phone and in person.

  • Must possess energy and drive to coordinate multiple projects simultaneously.

  • Ability to use tact and diplomacy to maintain effective working relationships

Preferred Qualifications

1-2 years of experience strongly preferred

All are welcome

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or

icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Postdoctoral Research Fellow

Providence Health & Services

Posted 4 days ago

VIEW JOBS 9/23/2020 12:00:00 AM 2020-12-22T00:00 Providence is calling a Postdoctoral Research Fellow to Providence Cancer Institute in Portland, Oregon. This is a full-time, 3-year term position with full benefits. Providence is seeking a highly motivated and hardworking individual to join the Cancer Immunoprevention Laboratory as a Postdoctoral fellow at the Earle A. Chiles Research Institute (EACRI) at the Providence Cancer Institute. The primary investigator of this laboratory is Sasha Stanton, a breast oncologist and translational researcher who has recently joined the EACRI group. The major goal of this lab is translational research to understand the immune environment of pre-invasive lesions, specifically ductal carcinoma in situ and oral dysplasia, and develop immune-based therapies to treat these lesions and prevent multi-antigen vaccines to both treat these lesions and prevent invasive cancers. The fellowship will be focused on studying the immune environment of oral dysplasia and head and neck squamous cell carcinoma, identifying tumor-associated antigen targets, and designing pre-clinical models of a multi-antigen vaccine for oral dysplasia with the goal of submitting an IND to start early phase clinical trials. The Postdoctoral Research Fellow will be expected to apply for external funding within 2 years of their assignment and are expected to submit at least one 1st author manuscript within the first 3 years of their assignment; then one per year thereafter. The candidate must be able to both work independently and collaboratively as part of a larger team. Outstanding organizational skills, great attention to detail, excellent communication skills, and high scientific integrity and rigor are essential. A strong working knowledge of human immunology, familiarity with transgenic mouse tumor models of cancer, and experience in T cell biology are major assets. Other assets include experience with immunological techniques such as multicolor flow cytometry, immunohistochemistry and immunofluorescence, ELISA, ELISPOT, and familiarity with MHC class II epitope prediction algorithms. In this position you will have the following responsibilities: * Design and execute experiments, data analysis, presentation of results, preparation of manuscripts, and training and education of students and peers. * Develop and or implement changes for scientific plans and protocols to accomplish specific scientific objectives. * Independently perform, document and report research results of complex biomedical experiments in support of research activities or specialized scientific laboratory. * Independently develop methods, techniques, and evaluation criteria for solving problems. * Summarize and interpret data; write manuscripts and presents findings in a form suitable for publication or other special reports; present research findings to local and national groups. * Prepare and conduct in vivo and in vitro experiments as necessary. * Stay current with the literature in ongoing and proposed research projects in the field of specialty. * Remain cognizant of potentially hazardous chemical, biological, or radiological materials; uses personal protective equipment; and adheres to strict safety protocols. Required qualifications for this position include: * Ph.D. in immunology or related field. * Advanced training with in vivo procedures, including murine colony management, genotyping, intravenous injections and in vivo infection or tumor models * Experience in presenting original research in oral and written format is essential, as is proven success in writing and publishing original research * Experience with in vivo procedures, including murine colony management, genotyping, intravenous injections and in vivo infection or tumor models * Demonstrates a track record of progressive biomedical research that indicates a growing level of research independence Preferred qualifications for this position include: * Ph.D. in Immunology -OR- Experience in the field of Immunology About Providence in Oregon As the largest healthcare system and largest private employer in Oregon, Providence offers exceptional work environments and unparalleled career opportunities. The Providence Experience begins each time our patients or their families have an encounter with a Providence team member and continues throughout their visit or stay. Whether you provide direct or indirect patient care, we want our patients to feel that they are in a welcoming place where they can be comfortable and free from anxiety. Our employees create the Providence Experience through simple, caring behaviors such as acknowledging and welcoming each visitor, introducing ourselves and Providence, addressing people by name, providing the duration of estimated wait times and updating frequently if timelines change, explaining situations in a way that puts patients at ease, carefully listening to their concerns, and always thanking people for trusting Providence for their healthcare needs. At Providence, our quality vision is simple, "Providence will provide the best care and service to every person, every time." Providence is consistently ranked among the top 100 companies to work for in Oregon. It is also home to two of our award-winning Magnet medical centers. Providence hospitals and clinics are located in numerous areas, ranging from the Columbia Gorge to the wine country to sunny southern Oregon to charming coastal communities to the urban setting of Portland. If you want a vibrant lifestyle while working with a team highly committed to the art of healing, choose from our many options in Oregon. Providence Health & Services Portland OR

Postdoctoral Researcher