The Xavier Lab in the Infectious Diseases and Microbiome program of The Broad Institute of MIT/Harvard is looking to hire a Postdoctoral Associate with a strong background in the functional genomics of autophagy. The laboratory of Dr. Ramnik Xavier (Core Member of the Broad Institute and Director of the Center for Computational and Integrative Biology at Massachusetts General Hospital) leverages clinical data from one of the world's leading hospitals and large scale chemical biology and genetics experiments performed at the Broad.
Recently, the lab has discovered how polymorphisms in genes such as GPR65, C1orf106, and CARD9 can influence development and progression of disease by affecting processes including lysosome function, intestinal barrier integrity, and innate/adaptive immunity. Autophagy is altered in several diseases and elucidating its regulatory mechanisms will advance our understanding how cells defend against pathogens and potentially identify new therapeutic modalities.
Postdoctoral researchers closely interact with a dynamic team of Broad Institute scientists and to pursue fundamental research questions, with an emphasis on novel discoveries that will result in high impact publications. This position focuses on developing new a approaches to study how the autophagy pathway maintains cellular homeostasis by regulating lysosomal degradation of misfolded proteins, damaged mitochondria, and intracellular pathogens.
Excellent experimental and organization skills
Ph.D. or M.D./Ph.D. in immunology, cell biology or molecular biology. Areas of focus include: mechanisms of selective autophagy, role of autophagy in immune disorders, mouse models, and CRISPR-based functional screening
Strong publication record
Familiarity with functional genetic and/or genomic data is preferred
Ability to communicate scientific material and work well in a collaborative environment
EOE / Minorities / Females / Protected Veterans / Disabilities
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The Broad Institute