Postdoctoral Research Associate-Carter/Liu/Brustad Lab

The University Of North Carolina Chapel Hill , NC 27516

Posted 2 months ago

"Molecular biologist/protein scientist/enzymologist is needed to work with a team of co-investigators including Charles Carter (Biochemistry and Biophysics), Rihe Liu (Medicinal Chemistry) and Eric Brustad (Chemistry) at the University of North Carolina at Chapel Hill on a project entitled ""Templated Cross-Catalysis by Oligonucleotides and Oligopeptides"" recently funded by the Templeton Foundation via the Foundation for Applied Molecular Evolution (Ffame). We wish to demonstrate and quantitatively measure the catalysis by polypeptides and elongation reactions on RNA substrates, and reciprocally, catalysis of peptide ligation and elongation reactions of polypeptides." Experimental experience in biocatalysis and in the analysis of peptide and protein:nucleic acid interactions would be preferred. UNC Chapel Hill provides a collaborative and stimulating environment for this project, as well as close ties to numerous technologies associated with protein design and combinatorial therapeutic generation.PhD in Biological Sciences is preferred


icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Postdoctoral Research AssociateManess Lab

The University Of North Carolina

Posted 2 months ago

VIEW JOBS 8/16/2019 12:00:00 AM 2019-11-14T00:00 The Maness laboratory is in the Genetic Medicine Building at UNC with access to outstanding imaging and core facilities through the UNC Neuroscience Research Center and Carolina Institute for Developmental Disabilities. The environment offers a rich venue for training in molecular developmental neuroscience. Our laboratory focuses on the mechanisms of circuit formation by neuronal cells in the mammalian brain. Neural cell adhesion molecules (CAMs) are key regulators of neuronal processes and synaptogenesis during postnatal adolescent development of the mammalian brain. Mouse gene knockouts implicate these adhesion molecules in axonal and dendritic growth during development and in learning and memory in the adult. To define the roles of CAMs in development of cortical circuitry, we are identifying the intracellular signaling cascades induced by binding interactions of these receptors using a combined approach of mouse genetic models, biochemistry, and molecular biology. The Postdoctoral Research Associate will develop novel mouse genetic models to identify molecular mechanisms of synapse regulation by GABAergic interneurons in the prefrontal cortex. Parvalbumin- and CCK-positive basket interneurons are unique in targeting the soma of cortical pyramidal cells, important for working memory and pyramidal cell synchrony. These classes of interneurons are defected in schizophrenia, thus it is important to understand their function and patterns of connectivity. New findings implicate these interneurons in remodeling synaptic connections during adolescent development through ephrinA/EphA receptor signaling to achieve the appropriate balance of excitatory and inhibitory connections in the prefrontal cortex. The project will use mouse genetic mutants, 2 photon microscopy, live imaging of neurons in brain slices, and cell/biochemistry to elucidate mechanisms of synaptic remodeling in adolescent development. Training in electrophysiology, molecular modeling of protein interactions, and mouse behavioral testing can also be involved. The program of study is relevant both to normal development and neurodevelopmental disorders. We have an outstanding group of talented and interactive lab members, and a great environment in the Department of Biochemistry and UNC Neuroscience Research Center. An educational background in molecular neurobiology is required. Experience in cell culture, microscopy, molecular biology, and biochemistry is desired. A successful candidate will have the opportunity to compete for independent postdoctoral fellowhips.PhD in Biochemsitry and Biophysics and or related field of study in science with a background in neuroscience. The University Of North Carolina Chapel Hill NC

Postdoctoral Research Associate-Carter/Liu/Brustad Lab

The University Of North Carolina