Postdoctoral Research Associate

St. Jude Children's Research Hospital Memphis , TN 38103

Posted 2 months ago

Summary

The laboratory of Dr. Taosheng Chen studies the roles of nuclear xenobiotic receptors (PXR, CAR) and drug-metabolizing enzymes (CYP3A) in tumorigenesis and cancer drug resistance. We use multidisciplinary approaches to investigate signaling pathways, identify and validate targets, and develop chemical probes to interrogate the function of PXR, CAR and CYP3A in order to overcome drug resistance and tumorigenesis in cellular and animal models (Lin et al, Nat Commun. 8:741, 2017).

Responsibilities

The postdoctoral fellow will work on one or more of the following projects:

  • Transcriptional and splicing regulation of PXR and CYP3A in human cancers;

  • Mechanism of action of chemical probes, including bi-functional compounds such as PROTACs;

  • Biophysical analysis and modeling of small molecule - protein interactions;

  • Signal cross-talk between drug metabolism and energy metabolism pathways;

  • Target discovery by data mining approaches followed by experimental validation.

The Chen Lab provides a unique training environment: in addition to basic research on transcriptional/ post-transcriptional regulation, the postdoctoral fellow will learn and gain experience in small molecule drug discovery from target identification, compound screening to preclinical studies. Former Chen Lab postdocs have landed jobs as Assistant Professors in Universities or Senior Scientist in Pharmaceutical Companies.

The successful candidate will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists and structural biologists (https://www.stjude.org/chen).

Minimum Education

Highly motivated individuals with a strong publication record are encouraged to apply. A strong interest in studying transcriptional/post-transcriptional regulation, together with experience either in cell and molecular biology, protein biochemistry and structural biology, molecular pharmacology, large-scale data mining or RNA biology, are desirable. Candidates must have (or soon receive) a PhD degree.

Contact Information

Taosheng Chen, PhDMember (Professor), Department of Chemical Biology and Therapeutics

St. Jude Graduate School of Biomedical Sciences

Director, High Throughput Bioscience CenterSt. Jude Children's Research Hospital262 Danny Thomas PlaceMemphis, TN 38105-2794

USAPhone: 1-901-595-5937 Fax: 1-901-595-5715Email: taosheng.chen@stjude.orgWebsite: http://www.stjuderesearch.org/chen/

EEO

St. Jude is an Equal Opportunity Employer

No Search Firms:

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities.

Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.



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Postdoctoral Research Associate

St. Jude Children's Research Hospital