The laboratory of Dr. Taosheng Chen studies the roles of nuclear xenobiotic receptors (PXR, CAR) and drug-metabolizing enzymes (CYP3A) in tumorigenesis and cancer drug resistance. We use multidisciplinary approaches to investigate signaling pathways, identify and validate targets, and develop chemical probes to interrogate the function of PXR, CAR and CYP3A in order to overcome drug resistance and tumorigenesis in cellular and animal models (Lin et al, Nat Commun. 8:741, 2017).
The postdoctoral fellow will work on one or more of the following projects:
Transcriptional and splicing regulation of PXR and CYP3A in human cancers;
Mechanism of action of chemical probes, including bi-functional compounds such as PROTACs;
Biophysical analysis and modeling of small molecule - protein interactions;
Signal cross-talk between drug metabolism and energy metabolism pathways;
Target discovery by data mining approaches followed by experimental validation.
The Chen Lab provides a unique training environment: in addition to basic research on transcriptional/ post-transcriptional regulation, the postdoctoral fellow will learn and gain experience in small molecule drug discovery from target identification, compound screening to preclinical studies. Former Chen Lab postdocs have landed jobs as Assistant Professors in Universities or Senior Scientist in Pharmaceutical Companies.
The successful candidate will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists and structural biologists (https://www.stjude.org/chen).
Highly motivated individuals with a strong publication record are encouraged to apply. A strong interest in studying transcriptional/post-transcriptional regulation, together with experience either in cell and molecular biology, protein biochemistry and structural biology, molecular pharmacology, large-scale data mining or RNA biology, are desirable. Candidates must have (or soon receive) a PhD degree.
Taosheng Chen, PhDMember (Professor), Department of Chemical Biology and Therapeutics
St. Jude Graduate School of Biomedical Sciences
Director, High Throughput Bioscience CenterSt. Jude Children's Research Hospital262 Danny Thomas PlaceMemphis, TN 38105-2794
USAPhone: 1-901-595-5937 Fax: 1-901-595-5715Email: firstname.lastname@example.orgWebsite: http://www.stjuderesearch.org/chen/
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