Postdoctoral Fellow-Immunotherapeutic Design

Pfizer La Jolla , CA 92037

Posted 2 months ago

ROLE SUMMARY

The Cancer Immunology Discovery (CID) group in La Jolla, CA, generates large molecule immunotherapeutics that promote anti-tumor activity or counter immunosuppression in the tumor microenvironment.

Together with the Oncology Medicinal Chemistry group that focuses on the structure elucidation of protein small molecule complexes with anti-tumor efficacy, we are seeking a qualified candidate to join us as a Postdoctoral Fellow.

The successful candidate will work across both groups to elucidate the structural basis of unconventional peptide presentation by MHC I molecules and the effect on activation of CD8+ T cells and NK cells.

The candidate will design HLA allele-specific peptides, characterize their interaction with MHC class I using protein crystallography, and assess their activity in vitro assays.

ROLE RESPONSIBILITIES

  • Expression of MHC I alleles and refolding with designed peptides using established refolding methods

  • Structure determination of MHCI-peptide complexes using X-ray crystallography

  • Measuring NK cell activation using cytotoxicity assays

  • Staining of CD8+ T cells and NK cells using flow cytometry

  • Dissemination of results via peer-reviewed publications and presentations

BASIC QUALIFICATIONS

  • Recent PhD in Immunology, Biochemistry, or related discipline with first author publication(s) in peer-reviewed and internationally renowned journals

  • Technical expertise in protein expression and purification, as well as protein crystallography.

  • Cell-culture, cytotoxicity assays (e.g DELFIA immunoassay)

  • The ability to plan and execute experiments independently

PREFERRED QUALIFICATIONS

  • Flow cytometry experience

  • Protein-protein/ Protein-cell interactions (SPR, BLI, FCM)

  • Strong understanding of molecular biology and protein biochemistry.

  • Motivated, proactive, and eager to learn.

  • Excellent communication and presentation skills.

  • Advanced molecular design proficiency.

Eligible for Employee Referral Bonus

Eligible for Relocation Package Benefit

#LI-PFE

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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Postdoctoral Fellow-Immunotherapeutic Design

Pfizer