Postdoctoral Fellow-Immunotherapeutic Design

Pfizer La Jolla , CA 92037

Posted 2 months ago


The Cancer Immunology Discovery (CID) group in La Jolla, CA, generates large molecule immunotherapeutics that promote anti-tumor activity or counter immunosuppression in the tumor microenvironment.

Together with the Oncology Medicinal Chemistry group that focuses on the structure elucidation of protein small molecule complexes with anti-tumor efficacy, we are seeking a qualified candidate to join us as a Postdoctoral Fellow.

The successful candidate will work across both groups to elucidate the structural basis of unconventional peptide presentation by MHC I molecules and the effect on activation of CD8+ T cells and NK cells.

The candidate will design HLA allele-specific peptides, characterize their interaction with MHC class I using protein crystallography, and assess their activity in vitro assays.


  • Expression of MHC I alleles and refolding with designed peptides using established refolding methods

  • Structure determination of MHCI-peptide complexes using X-ray crystallography

  • Measuring NK cell activation using cytotoxicity assays

  • Staining of CD8+ T cells and NK cells using flow cytometry

  • Dissemination of results via peer-reviewed publications and presentations


  • Recent PhD in Immunology, Biochemistry, or related discipline with first author publication(s) in peer-reviewed and internationally renowned journals

  • Technical expertise in protein expression and purification, as well as protein crystallography.

  • Cell-culture, cytotoxicity assays (e.g DELFIA immunoassay)

  • The ability to plan and execute experiments independently


  • Flow cytometry experience

  • Protein-protein/ Protein-cell interactions (SPR, BLI, FCM)

  • Strong understanding of molecular biology and protein biochemistry.

  • Motivated, proactive, and eager to learn.

  • Excellent communication and presentation skills.

  • Advanced molecular design proficiency.

Eligible for Employee Referral Bonus

Eligible for Relocation Package Benefit


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Postdoctoral Fellow Cancer Targets And New Drug Discovery

Sanford Burnham Prebys Medical Discovery Institute

Posted 1 week ago

VIEW JOBS 5/23/2020 12:00:00 AM 2020-08-21T00:00 Sanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health. Our scientists are making research breakthroughs in cancer, neuroscience, immunology, and children's disease. We are also at the forefront of finding solutions for emerging health threats such as COVID-19, where we are working to identify drugs that may help millions of people. During our more than 40 year history, we have established an NCI-designated Cancer Center, designed one of the most sophisticated drug discovery centers in the nonprofit world, and created global collaborations that are leading to preventions, treatments and cures to improve human health. SBP is currently accepting internal applications for postdoctoral training in our exciting T32 Program: Cancer Targets and New Drug Discovery. The goal of this 2-year training program is to establish an innovative multi-thematic graduate student and postdoctoral training program to train the next generation of leaders in cancer target discovery and validation, cancer drug discovery, and biomarker development. Through this program, advanced graduate students and postdocs will be trained in the skills needed to execute a successful cancer drug discovery project using novel paradigms and state-of-the-art technologies. The program includes a 2-month biotech company internship and training in scientific entrepreneurship. Postdoctoral participants in the program will expand a research project to include any of the following specific aims of the program: 1) The discovery and validation of novel cancer drug targets in the context of signaling networks, mechanisms of genetic and epigenetic regulation, and exploring non-traditional targets. 2) The discovery of small molecule probes to interrogate novel cancer targets. 3) The pursuit of mechanistic studies of cancer signaling pathways using probe inhibitors. 4) The exploration of entrepreneurship in cancer drug discovery. In addition to scientific training, postdocs will participate in professional development programs through which they will gain skills in leadership and management, as well as an understanding of the vast array of career paths available to them following their education and training. TO APPLY: Interested postdoctoral and graduate student candidates should apply online to the SBP career site. Click the link below and submit the attached application along with one PDF document with a cover letter, CV, references and research statement. Sanford Burnham Prebys Medical Discovery Institute La Jolla CA

Postdoctoral Fellow-Immunotherapeutic Design