The Cancer Immunology Discovery (CID) group in La Jolla, CA, generates large molecule immunotherapeutics that promote anti-tumor activity or counter immunosuppression in the tumor microenvironment.
Together with the Oncology Medicinal Chemistry group that focuses on the structure elucidation of protein small molecule complexes with anti-tumor efficacy, we are seeking a qualified candidate to join us as a Postdoctoral Fellow.
The successful candidate will work across both groups to elucidate the structural basis of unconventional peptide presentation by MHC I molecules and the effect on activation of CD8+ T cells and NK cells.
The candidate will design HLA allele-specific peptides, characterize their interaction with MHC class I using protein crystallography, and assess their activity in vitro assays.
Expression of MHC I alleles and refolding with designed peptides using established refolding methods
Structure determination of MHCI-peptide complexes using X-ray crystallography
Measuring NK cell activation using cytotoxicity assays
Staining of CD8+ T cells and NK cells using flow cytometry
Dissemination of results via peer-reviewed publications and presentations
Recent PhD in Immunology, Biochemistry, or related discipline with first author publication(s) in peer-reviewed and internationally renowned journals
Technical expertise in protein expression and purification, as well as protein crystallography.
Cell-culture, cytotoxicity assays (e.g DELFIA immunoassay)
The ability to plan and execute experiments independently
Flow cytometry experience
Protein-protein/ Protein-cell interactions (SPR, BLI, FCM)
Strong understanding of molecular biology and protein biochemistry.
Motivated, proactive, and eager to learn.
Excellent communication and presentation skills.
Advanced molecular design proficiency.
Eligible for Employee Referral Bonus
Eligible for Relocation Package Benefit
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Research and Development