Postdoctoral Fellow In Medicine - Hematology/Oncology

Title Postdoctoral Fellow in Medicine

• Hematology/Oncology Specific Title Postdoctoral Fellow

• Acquired Chemoresistance in Small Cell Lung Cancer Appointment Type Postdoctoral Fellow Department IUSM - Medicine

• Hematology/Oncology Campus IU School of Medicine Indianapolis Position Summary

A postdoctoral position in the laboratory of Dr. Shields is available to work in translational research studies in lung cancer. Highly motivated individuals with a PhD in the area of molecular biology, drug discovery, genomics, epigenetics, cancer biology, or related fields are encouraged to apply. This position is to perform comprehensive genomics, functional characterization, and drug screening from top hits discovered in patient samples from longitudinal liquid biopsies, along with cell lines and xenografts, to identify mechanisms leading to acquired chemoresistance in small cell lung cancer. The successful candidate will use genomic, epigenetic, and cellular studies to determine how dysregulated epigenetic and expression signatures can lead to therapeutic vulnerabilities that can be leveraged to prevent disease progression and relapse.

Duties or techniques may include, but are not limited to, the following:

• Tissue culture

• Lentiviral transduction

• Western blotting, cellular and protein analysis

• ChIP-seq

• CRISPR/Cas9 mutagenesis

• Animal models

• Drug sensitivity assays

• Flow cytometry

• Skills to analyze large data including NGS, methylation, and microarray results

• Maintaining accurate records of experiments and results

• Communicating with other team members and senior departmental members

• Presenting data locally and at national and international meetings

IUSM is committed to being an institution that reflects the learners we teach and the patient populations we serve and pursues the values of equity and inclusion that inform academic excellence. We desire candidates whose work contributes to equitable and inclusive learning and working environments for our learners, staff, and faculty. We invite individuals who will join us in our mission to improve health equity and well-being for all throughout the state of Indiana.

Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life - the city possesses a variety of professional sports, arts venues and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named "Best Airport in North America" by Airports Council International for many years. For additional information on life in Indy: https://faculty.medicine.iu.edu/relocation

The search committee will begin evaluating applications as they are received and applications will continue to be reviewed until positions are filled.

Basic Qualifications

Doctorate or terminal degree required. The candidate should be highly motivated with a PhD in the area of cell and molecular biology, genomics, epigenetics, drug discovery, cancer biology, or a related field. The candidate must be diligent, rigorous, able to work independently, approachable, and have an attention to detail.

Department Contact for Questions

Sabrina Hetzel

snwall@iu.edu

Additional Qualifications Special Instructions Priority Application Review Deadline Expected Start Date OAA # IUSM-01752-2023