Postdoctoral - Brain Tumors (Richardson Lab)

Title Postdoctoral - Brain Tumors (RICHARDSON LAB) Specific Title Appointment Type Postdoctoral Fellow Department IUSM - Neurological Surgery Campus IU School of Medicine Indianapolis Position Summary

A full-time Post-Doctoral Research position is available in the Department of Neurological Surgery to conduct studies on the tumor microenvironment in primary (glioma, medulloblastoma) and secondary brain tumors. We will use replicating retroviral vector (RRV) gene therapies to interrogate treatment efficacy and immune responses in the tumor microenvironment. Our research will also focus on the effects of oxygen tension (hypoxia vs normoxia) on the efficacy of viral therapy, chemotherapy, and immune responses both in vitro and in vivo. We are seeking a self-directed, self-motivated, curious, creative, well-organized candidate with extensive experience in molecular biology, next-generation sequencing techniques, data analysis, and animal handling to join our team.

Job Summary

Primary Duties and Responsibilities:

• Advanced molecular biology techniques including gene editing, plasmid design and production, bacterial culture, plasmid purification, and related analyses.

• Molecular biology and biochemical analyses including Western blotting, protein assays, PCR, RT-PCR, DNA and RNA purification and sequencing.

• Animal (mouse) handling/manipulations: Perform surgeries/implantations (will train), biopsies, bioluminescence imaging, and drug administration.

• Extensive tissue culture experience required.

• Flow cytometry and microscopy; phenotypic analysis and imaging.

• Keep organized analytical data of performed experiments and expected to report findings at lab meetings.

• Acts as a liaison/mentor to technicians, students and other laboratory personnel for training.

• Responsible for the initiation, monitoring, completion, and reporting of complex and intricate laboratory experiments. Organize and implement data review and analysis.

• Collaborate with other University Faculty and labs for common goals.

• Expected to keep current on relevant literature to identify suitable direction, new techniques, procedures and methods.

• Expected to submit research to national, professional meetings for possible presentations.

• Expected to publish in peer reviewed journals.

IUSM is committed to being an institution that reflects the learners we teach and the patient populations we serve and pursues the values of equity and inclusion that inform academic excellence. We desire candidates whose work contributes to equitable and inclusive learning and working environments for our learners, staff, and faculty. We invite individuals who will join us in our mission to improve health equity and well-being for all throughout the state of Indiana.

Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life - the city possesses a variety of professional sports, arts venues and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named "Best Airport in North America" by Airports Council International for many years. For additional information on life in Indy: https://faculty.medicine.iu.edu/relocation.

Basic Qualifications

EDUCATION

Required

• Bachelor's degree in science or a related field

• Doctorate degree (PhD) in science or a related field or terminal degree required

SKILLS

Required

• Experience with broad range of molecular biology and biochemistry techniques

• Extensive tissue culture experience

• Maintains a high degree of professionalism

• Demonstrated time management and priority setting skills

• Experience in animal husbandry and related studies (e.g. mouse IP/IV drug administration and tissue dissection)

Preferred

• Neurological cell culture; both primary and established cell lines

• Some bioinformatics experience

Department Contact for Questions

Angela Richardson (angmrich@iu.edu)

Additional Qualifications Special Instructions Priority Application Review Deadline Expected Start Date 07/01/2024 OAA # IUSM-02002-2024