Postdoctoral Associate (Development, Aging And Regeneration) D'angelo Lab

Sanford Burnham Prebys Medical Discovery Institute La Jolla , CA 92037

Posted 3 weeks ago

Sanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health.

The D'Angelo laboratory has a Postdoctoral Associate position available in the areas of immune regulation, skeletal muscle and cancer.

The main focus of the D'Angelo's laboratory is to study the role of Nuclear Pore Complexes, the multi-protein channels that connect the nucleus with the cytoplasm. Using a combination of cell biology, imaging and animals models the lab seeks to understand how nuclear pores regulate the physiology of different tissues and to establish how alterations in the function of these structures contribute to cellular malfunction and disease. The D'Angelo laboratory also has a strong emphasis in the translation of basic discoveries into clinical applications.

The Postdoc Associate will focus on increasing our understanding of the regulation of tissue homeostasis by nuclear pore complexes and other components of the nuclear transport machinery. The successful candidate will be part of a highly collaborative research team and will have the opportunity to work with advanced techniques in molecular and cellular biology, genetics, imaging, and models of disease. The candidate is expected to play a key role in dissecting the mechanisms of function of components of the nuclear transport system and in establishing their potential therapeutic implications for muscle disease and cancer. Some studies may involve the identification of novel drug targets, the development of high throughput screening assays and small molecule screening campaigns.

TO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter, CV, references and list of any publications or accomplishments.

View these links on the current research in the D'Angelo lab:

Killing cancer by blocking cell doors

Scientists kill cancer cells by "shutting the door" to the nucleus

Celebrating the next generation of biomedical trailblazers at the 19th annual Fishman Fund Awards

Primary Responsibilities

  • Independently designs and performs experiments and procedures with high degree of complexity, demonstrating increasing expertise with a wide range of techniques

  • Demonstrates flexibility in adapting methods and skills according to evolving project priorities

  • Provides independent experimental design and planning

  • Analyzes and interprets data from different sources and draw relevant conclusions

  • Presents results at internal and external meetings

  • Accurately documents experiments

  • Contributes to writing of reports and manuscripts with increasing responsibility over time

  • Works collaboratively across lab functions and trains other junior lab staff as needed

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Postdoctoral Associate (Development, Aging And Regeneration) D'angelo Lab

Sanford Burnham Prebys Medical Discovery Institute