Pfizer: Senior Scientist, Single Cell Immune Profiling

WHY PATIENTS NEED YOU

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

POSITION SUMMARY

We are seeking a highly motivated senior scientist with a passion for using high-dimensional single cell immune profiling data in conjunction with innovative computational approaches and systems immunology knowledge to transforming vaccine research. Responsibilities will be developing analytical tools used for bulk RNAseq, single cell RNAseq, TCR sequencing, BCR sequencing, and host immune profiling. This role will integrate multi-omics data with preclinical/clinical data and provide scientific insights to immune responses elicited by vaccines or pathogens. This person will collaborate in a cross-functional teams and make strong impact to all stages of vaccine R&D.

KEY RESPONSIBILITIES

• Participate in designing immune profiling experiments for pre-clinical animal studies or clinical trials.

• Familiar with state-of-art technology related to bulk RNAseq, single cell RNAseq, TCR profiling, and BCR profiling.

• Analyze and integrate multi-omics data with pre-clinical data or clinical data.

• Provides scientific insights to innate and adaptive immune responses induced by adjuvanted vaccines and guides adjuvant optimization or vaccine design.

• Identify immune signature or prediction biomarkers of vaccine efficacy or disease progression.

• Communicate study findings efficiently and present data at various meetings as projects progress.

• Collaborate extensively with those from other scientific disciplines from within the group, from other subdivisions of Vaccines R&D, from other divisions of Pfizer, and potentially from external partners.

MINIMUM QUALIFICATIONS

• Ph.D. in Immunology or Computational Biology with a focus on the immune system, or related fields.

• 5+ years of relevant research experience in applying single cell immune profiling approaches to solving biomedical problems.

• Expertise in viral or bacterial immunology, or vaccine and pathogen induced innate and adaptive immune response.

• Extensive experience in analyzing multi-omics data (e.g., genetics, bulk RNA-seq, single-cell RNA-seq, spatial omics, proteomics, etc.) for biomedical research.

• Proficient coding/scripting in Python, R.

• Familiar with Linux environments, high-performance computing and/or cloud computing environment and broad experience with open-source bioinformatics tools to generate immunological insight.

• Be comfortable with fast-paced environment handling multiple projects simultaneously with different priorities and timelines. Strong motivation, passion and commitment to interdisciplinary science and techniques.

PREFERRED QUALIIFICATIONS

• Additional 1-3 years of related systems immunology or systems vaccinology experience (post-PhD) is preferred.

• Extensive hand-on experience generating immunological insight from single cell sequencing data is highly desirable.

• Strong experience processing diverse single-cell raw data using Cell Ranger and alternative/open-source pipelines.

• Strong experience with scVerse tools, scVi tools, or Seurat, as well as antigen-specific analysis using scRepertoire, Immcantation, or related tools.

Relocation support available

Work Location Assignment:On Premise

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development