MBA Intern Business Development, Summer 2019

Regeneron Pharmaceuticals Tarrytown , NY 10591

Posted 3 months ago

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

We are seeking a talented MBA student who is passionate about science and the business of biotechnology to join the Regeneron Business Development team for a summer internship. Previous Business Development interns have had the opportunity to support the group's broader strategic goals by both 1) executing specific, summer-long projects that are centered aound a particular strategic analysis of a potential business or partnering opportunity, and 2) working side-by-side with BD team members on live transactions to support due diligence, strategic/business analysis, and negotiations.

Education

  • Current 1st Year MBA student

  • Business or Science background required

Skills

  • Self-Starter with an entrepreneurial spirit;

  • Strong organizational skills; ability to effectively manage multiple projects and priorities

  • Strong project management, analytical, critical thinking skills, and interpersonal skills

  • Demonstrated academic strength and leadership skills

  • Integrity and commitment to high ethical standards

  • Interpersonal, presentation, oral, and written communication skills

Transportation and Housing

  • A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown campus

  • Get to know other incoming Interns on our closed LinkedIn page when you accept an offer

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.


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Formulation Development Intern Summer 2019

Regeneron Pharmaceuticals

Posted 1 week ago

VIEW JOBS 1/10/2019 12:00:00 AM 2019-04-10T00:00 Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. These positions are in Formulation Development in Tarrytown, NY. There are 6 openings for Summer 2019. Each opening is described below. Position 1: To ensure shelf life and stability of protein therapeutics over time, it is important to develop robust, sensitive, and precise methods to monitor critical quality attributes of protein drugs. Analysis of the stability of proteins is conducted with a variety of analytical and biophysical assays and techniques that assess chemical and physical modifications that contribute to breakdown of active drug molecules. The student will participate in method development and characterization (pre-validation) of capillary electrophoresis and liquid chromatography-based methods, especially charge and size-based analyses of protein therapeutics. For example, within the scope of this work will be assessment of experimental factors/method parameters that may influence the response accuracy and precision of capillary electrophoresis methods. The project will also involves application of the concepts of design of experiment in analytical method development, statistical analysis of response data through model fitting, factor interaction analysis etc. Position 2: The student will gain a mechanistic understanding of excipient-induced viscosity reduction of high concentration mAb formulations by investigating thermodynamic stability and/or higher order structural properties of mAb molecules in presence of viscosity modifiers. Position 3: The Formulation Development Group has been staging and evaluating research stability studies as part of drug product and formulation development. The data may be used to support shelf life of clinical material based on program needs. The use of research stability study is becoming a standard approach for shelf life assignment with more and more accelerated CMC development programs. However, the shelf life assignment based on research stability studies has been capped at 12 months due to the differences in analytical methods between research and GMP stability studies. Recently, a new research stability testing strategy has been proposed such that critical methods supporting stability testing will be perform following procedures aligned with GMP area to minimize the differences in test methods and alleviate Quality concern. A comparability assessment is proposed here to evaluate the stability profile and trend degradation rate of both research and GMP studies following the new testing strategy to support shelf life assignment beyond 12 M. Position 4: Sustained release dosage forms of therapeutic proteins are strongly desired to address the unmet needs for reducing injection intervals or improving patient compliance. While the controlled release properties are normally achieved through encapsulating the drug into biodegradable polymer microparticles, successful encapsulation with high efficiency, high drug loading, and low burst release are still challenging using conventional water-oil-water emulsion-based methods. To that end, developing a non-aqueous approach to fabricate microspheres would have the advantages of enhanced protein encapsulation efficiency and minimized process-induced protein denaturation by excluding water in the manufacturing process. The student will work on the process optimization and scale up of the non-aqueous microsphere production method for bulk-emulsification or microfluidic based approach. The effects of the process parameters on the drug loading, protein compatibility, microsphere size and structures, and in vitro sustained release properties will be investigated. Position 5: The student will focus on researching and implementing ways to achieve greater laboratory organization, standardization and efficiency in the Formulation Development Group. An example of such an approach is 5S. 5S is a lean operation tool designed to help improve workplace efficiency through facility organization and elimination of non-value adding processes. 5S promotes safe and efficient work routines while decreasing training time and inventory search times. The project will consist of integrating the essential steps of 5S i.e. sort, set to order, shine, standardize and sustain. The student will work closely with existing team members to evaluate current space utilization, and work flow procedures within the Formulation Development Laboratories. The intern will be responsible for researching, sourcing and developing a proposal of practical and novel organizational tools, techniques and equipment applicable for existing Formulation Development laboratory floor plans, analytical equipment and required research and development work processes. The intern will prepare a strategic plan for execution of each stage of the 5S program for all Formulation Development laboratory areas, and work procedures prior to implementation. As essential part of the proposal will be a well-defined sustainability plan. The intern will propose best practices and create written documents/ operating procedures to facilitate compliance and sustainability. Position 6: The goal of the project is to screen formulations suitable to produce lyophilized antibody drug products and to develop physical and statistical models to predict the stability and physical properties of the antibody drug products. The specific duties include excipient screening, lyophilization, stability testing, measurement of chemical and physical degradation products and measurement of physical properties such as viscosity and osmolality. The student will gain experience in formulation screening, analytical testing, experiment design, statistical analysis of experimental data and lyophilization of monoclonal antibodies. Start building your skills at Regeneron. * Must be a graduate or PhD student, Position 5: Must be an undergraduate student * Must be pursuing a degree in Chemistry, Biochemistry, Chemical Engineering, Analytical Chemistry, Molecular Biophysics, Biology, or related * Must have basic laboratory experience * Position 1: Must have liquid chromatography and capillary electrophoresis experience * Position 2: Familiarity with calorimetry, spectroscopy, and rheology is preferred; One completed physical chemistry course is also preferred * Position 3: Familiarity with bioanalytics (Ex. HPLC, electrophoresis), statistical analysis, and theoretical knowledge of protein chemistry and stability is preferred. * Position 4: Must have academic research experience in controlled release or drug delivery. Must understand analytical methods and instrumentation (U/HPLC-based chromatographic techniques). Must have a basic understanding of common protein degradation pathways. Biochemistry, Chemistry, or Physical chemistry lab experience. Familiar with microscopy (optical, confocal, or SEM). and light scattering methods. * Position 5: Must have familiarity with inventory and supply management tools * Position 6: Must have experience with proteins, HPLC/UPLC, statistical software desired. Must have a good understanding of protein stability. Must have experience with academic research or industry experience in a laboratory setting doing sample preparation, analysis, data processing and analysis preferred. General Intern Program Information: * Must be enrolled in, or accepted to, an academic program pursuing a Bachelor's, Master's, PhD or PharmD * Summer Program is full-time (40 hrs/wk) for at least 10 weeks and is paid * Prefer demonstrated leadership in areas such as campus activities, clubs, sports or the community * Minimum GPA of 3.0 * You will work with a specific manager on a project(s) * Enjoy weekly 1 hour Intern Program events: learn about other areas of the company from VPs and other employees, soft skills workshops, networking, volunteering, and more! * Present to your team on your summer project Transportation and Housing: * A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown campus * Get to know other incoming Interns on our closed LinkedIn page when you accept an offer This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business. To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law. Regeneron Pharmaceuticals Tarrytown NY

MBA Intern Business Development, Summer 2019

Regeneron Pharmaceuticals