We seek an experienced and highly motivated senior biologist to join our growing drug discovery team. The individual will be responsible for target validation and preclinical proof-of-concept work supporting novel therapies for pulmonary and cardiometabolic disease, cancer, pathological fibrosis and other indications. Areas of responsibility will include preclinical validation of novel drug targets by establishing evidence of selective on-target drug activity and disease modification in animal models. The ideal candidate has experience in drug discovery / lead optimization and a strong understanding of the molecular biology of mammalian gene expression, RNAi and oligonucleotide therapeutics, with core competencies in correlating changes in gene expression with disease-modifying activity in vivo. The individual will be responsible for independent experimental design and execution, data analysis and communication.
Ph.D. in Biochemistry, Molecular Biology, Pharmacology, Cell Biology or a related discipline
Minimum of 6 years hands-on experience in early drug development research; industrial (biotech or pharma) or translational research experience
Excellent problem-solving skills in experimental design, data analysis and interpretation
Exceptional verbal and written communication skills
Proven ability to translate cutting edge research into drug development programs
Successfully collaborates with multidisciplinary teams of scientists and managers (biology, physiology, chemistry, toxicology, clinical, manufacturing)
Ability to lead and direct the daily activities of associate scientists
Experience working with contract research organizations and building relationships with academic collaborators
Ability to remain productive, organized and flexible in a dynamic and fast-paced cross-disciplinary environment
Preclinical translational biology experience in de-risking novel drug targets through mechanistic and disease-modifying proof of concept studies
Experience in oligonucleotide therapeutics discovery and early-stage development
Experience in the development of targeted drug delivery vehicles, including those designed for the delivery of nucleic acids such as RNA
Strong expertise in the use of animal models of disease
Arrowhead Pharmaceuticals, Inc.