Dmpk Director

We are seeking a DMPK Director with a high level of skill in pharmacokinetics and small molecule drug optimization through tuning ADME parameters and physico-chemical property space.

The focus of the role is to lead AstraZeneca's approach to optimize the pharmacokinetics of small molecule payloads conjugated to antibody drug conjugates (ADCs). This is a strategic and scientific role where you, together with Medicinal Chemists and project representatives from other disciplines, design our future therapeutic ADC drugs.

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of a person.

Welcome to R&D Boston site in Waltham, MA one of over 400 sites here at AstraZeneca. We provide a collaborative environment where everyone feels comfortable and able to be themselves.

This is at the core of AstraZeneca's priorities, and it's important to us that you bring your full self to work every day. To help you maintain your best self, here's a sneak peek into some of the things this site provides for you.

The site has a gym, nearby hiking trails, and an on-site cafeteria. There is a bright and spacious environment.

There is a vibrant social vibe including a happy hour, Lunch & Learn series, and a summer volleyball league. The R&D Boston site is also planning to relocate to a brand-new location at Kendall Square, Cambridge MA building in 2026.

Main Duties & Responsibilities:

It is your responsibility that the DMPK project team delivers the overall non-clinical DMPK, including pre-clinical PK, biotransformation and bioanalysis to early drug projects.

You are expected to have a solid understanding of DMPK and chemistry to be able to provide expert advice and interpretation of complex drug discovery data in relation to drug property space.

Apply an understanding of DMPK, physicochemical properties and biotransformation to support/influence compound design, project progression and project strategy.

Lead DMPK-related activities in your drug project, including the use of bespoke experiments and predictive models to ensure that DMPK challenges are thoroughly assessed and resolved.

Driving learning through back translation of early clinical exposure and PD data and providing prioritized future options for clinical testing.

Providing disciplinary scientific leadership and presenting work through patents, publications and lectures.

Minimum Qualifications:

• Bachelor of Science Degree

• At least three years inudstry experience in a DMPK lead role at a Pharmaceutical company

• High level of skill in pharmacokinetics (PK) and small molecule drug optimization

• Should demonstrate complete understanding of the pre-clinical PK and not only what factors influence individual PK parameters but also how to change the PK properties using analysis of physico-chemical property space and biotransformation knowledge: Provide Drug Projects tactics on how Program can get to desired end-point

Desirable Qualifications:

• PhD is desirable, but not required

• Ability to credibly influence whilst maintaining independent and objective views

• Communication, interpersonal and organizational skills

• Attention to detail and analytical thinking

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential.

Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods, and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Date Posted

13-Jun-2024

Closing Date

14-Jul-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process.

We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.