Director, Protein Sciences - Biotherapeutics
Req #: 1803174
Location: San Diego, CAUS
Job Category: Research and Early Development
Work Location: 4242 Campus Point Court Suite 300 CA-Genesis 92121
Employee Status: Full time
Job Type: Regular
Other Locations:US- CA- San Diego- Genesis
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
Director of Protein Sciences is a high impact leadership position. We seek a highly collaborative, motivated and innovative candidate with demonstrated expertise to provide scientific and technological leadership in protein design, production and biophysical/analytical characterization to enable biologics drug discovery and development. Qualified candidate will effectively operate in a "distributed drug discovery model" to enable advancement of biologics programs in multiple therapeutic areas, including oncology, inflammation and neurodegeneration. Key responsibilities include, manage a protein sciences team focused on the production and characterization of monoclonal antibodies, multi-specifics, antibody drug conjugates (ADC) and other protein therapeutics using state-of-art technology and an industry competitive DNA to protein production process. Contribute to research by managing scientific and technical activities based on an understanding of Research and Early development (R&ED) discovery and development needs. Initiate, present and defend research proposals to relevant project teams and governance committees within R&ED. Work with the leadership of various Thematic Centers of Excellence and function on creative approaches to discover high impact biologics. Maintains an external publication record and collaborative interactions with external experts in the field.
Responsibilities will include, but are not limited to, the following:
Provide insights/expertise to the strategy and implement the discovery of high quality biotherapeutics candidates
Operationalize an efficient state-of-art protein drug discovery platforms to produce and characterize monoclonal- and bispecific antibodies, fusion proteins and ADCs
Apply protein structural and biophysical principles to optimize protein function, stability and manufacturability of therapeutic candidates
Identify and implement new technologies/applications/external collaborations in support of research goals; interface with new technology providers. Participate in licensing and technology evaluation teams.
Manage the workflow of protein production and characterization unit to ensure quality, priorities and timelines.
Recruit, retain, and develop high quality staff; manage performance of direct and indirect reports
Supervise laboratory personnel in the execution of bench level activities
Identify and manage contract research laboratory for biologics discovery
Ph.D. in relevant field with in depth training in protein sciences, protein-protein interaction, protein and membrane biochemistry and biophysics
Minimum 12 years of experience in biologics drug discovery and development in biotech/pharmaceuticals
Three (3) years of managerial, leadership and supervisory skills at the Director level in the pharmaceutical industry
Subject matter expert in biologics discovery, protein structural biology and protein chemistry
Able to work independently as well as in a multi-discipline team environment
Ability to interface effectively with business partners
Excellent communication and interpersonal skills
Ability to multi-task; support multiple projects and set priorities based on business needs
Excellent written and oral communication skills
Ability to embrace a culture of continuous learning and improvement, increasing technical skills & disease biology expertise
Proactive role in personal growth, management and scientific development
Broad understanding of the R&D process.
Functional group advisor/go-to person.
Demonstrate broad understanding of Drug Discovery & Development.
Able to assess risk & develop contingency plans.
Recognized as expert in the field.
Serves as subject matter expert and functional group advisor on science, technology, methods, etc.
Familiar with basic business principles and focus of corporation.
Uses this knowledge to drive projects.
Role model for scientific excellence.
Familiar with industry trends and competitors position.
Tasks and Responsibilities:
Has accountability for scientific strategies and timelines.
Prioritizes risks and recommend or endorse contingency plans.
Developing others beyond functional expertise.
Viewed as subject matter expert across multiple scientific subjects.
Responsible for internal and external resources.
Coordinate cross functional activities.
Role model for scientific culture.
Develop cross functional strategy.
Communicate and make recommendations to line management.
Develops cross functional strategies.
Held accountable for cross functional strategies.
May develop cross functional policies.
Make recommendations to Senior Management and larger scientific community.
Guide/mentor/develop others in broad area of influence.
Creativity and Problem Solving:
Develop scientific directions for projects (strategy).
Acts as a resource to peers in developing new, innovative approaches to experimental design.
Independently (or using collaborations) develop scientific direction for assignments.
Recognize cross-functional issues.
Proposes innovative ideas to enhance Drug Discovery processes.
Teamwork and Influence:
Communicates within the larger organization and external community.
Provides expert guidance to multi-disciplinary teams and senior management.
Direct impact on the performance of multiple departments.
Impact is achieved through leading workgroups and contributing to cross-functional teams.
Leader who influences culture & values.
Able to conceptualize broad impact of research programs and personal activities in terms of whole
Structuring and staffing