Director Of Clinical Microbiology

Contrafect Corporation Yonkers , NY 10701

Posted 3 weeks ago

Job Application

Position: Director of Clinical Microbiology

Reports to - Vice President of Research


ContraFect Corporation, a clinical-stage biotechnology company focused on the discovery and development of protein therapeutics and antibody products for life-threatening, drug-resistant infectious diseases. We are committed to innovative drug development, leading the way with novel technologies to create new therapies that address the high unmet medical needs of patients suffering from serious infections for which there are limited available treatment options. The company is located in Westchester County, near New York City.

An opportunity is available to grow with us in an environment that is both challenging and energetic. ContraFect is seeking self-motivated and collaborative individuals to join our team and to contribute their talent and expertise. We are looking for positive individuals who will add to our committed and dedicated employee base and contribute to the development of novel therapeutic agents which have the potential to change the therapeutic landscape for treating serious infections.

It is an exciting time in our Company's history. CF-301, our lead compound, is the first and only bacteriophage-derived lysin (cell wall hydrolase) to enter clinical trials in the US. CF-301, which targets Staphylococcus aureus, including MRSA, is the first of a new class of protein-based therapeutics for the treatment of serious bacterial infections. CF-301 is currently being studied in a multinational, multicenter Phase 2 clinical trial for the treatment of S. aureus bacteremia including endocarditis. In addition to CF-301, we have an exciting pre-clinical and discovery pipeline of lysins targeting anti-biotic resistant gram positive and gram negative bacteria. Our primary focus in on developing treatments for bacteria designated by CDC and the WHO as urgent or serious threats of critical or high priority.

In addition, we are developing a triple antibody therapy for the potential treatment for serious influenza infections. We are using ContraFect's technical expertise to develop biotherapeutic products for infectious diseases that have high unmet medical needs, particularly products used in hospital-based markets.

Position Summary:

The Director will provide an important leadership role in Microbiology by overseeing the day to day operation of the ContraFect Microbiology Laboratory and the performance of clinical microbiology development studies in the field of protein-based therapeutics to treat serious bacterial infections. The laboratory is a major site for the conduct of clinical microbiologic testing of our lead compound, CF-301, in support of marketing authorization applications (NDA/BLA, MAA), approval and eventual clinical use if approved. Together with the VP of Research, the Director of Clinical Microbiology will institute quality metrics, work flows, cycle times and actively strive to increase the efficiency of the lab and the timeliness and quality of reports delivered by the research scientists. The laboratory conducts a wide range of Research activities including lysin identification and characterization, antimicrobial susceptibility testing, time kill assays, synergy studies, molecular cloning, protein engineering and optimization, research scale protein production and purification, in vitro microbiologic profiling, as well as bioassays to support preclinical studies (e.g. ELISAs, etc.).

The Director will have a key role in working directly with the VP of Research in the planning and implementing of all laboratory processes and procedures in addition to the forecasting of resource and equipment needs and the reporting of results from in vitro microbiology studies. The Director will also have the opportunity to conduct hands on research in support of ContraFect's Research efforts under the direction of the VP of Research, and is expected to publish and present at scientific meetings. The incumbent will be a key partner to the VP of Research and will work to continuously improve the technical performance of the lab across all domains, including the design, conduct and reporting of work conducted in the lab.

Importantly, the ContraFect Laboratory may also perform cell-based bioassays (e.g.lytic assay) as part of GMP drug substance and drug product release testing and stability protocols. The successful candidate will be responsible for ensuring quality and compliance in the conduct of the cell-based bioassay in accordance with the principles of GLP, in partnership with the Associate Director of Bioanalytics and Laboratory Operations, the VP of Research and the Quality team at ContraFect.


  • Organize and run a diverse microbiology laboratory with a wide research base, which includes handling, maintenance and study of pathogenic microorganisms, antimicrobial susceptibility testing (MIC, MBEC, checkerboard, time-kill, lytic assays, synergy studies, resistance determinations, etc.), mutagenesis and genetic screens, mechanism of action studies, identification and development of novel antimicrobial agents, as well as planning, scheduling and oversight of experiments

  • At the Direction of the VP of Research, support the operational activities associated with molecular cloning and plasmid production in coli, creative protein design and optimization, recombinant protein expression, purification, and characterization, DNA library preparation and screening, and cell-based activity assays

  • Design, validate, conduct and manage critical microbiologic experiments as directed by the VP of Research to advance ContraFect's discovery and development programs and to support discovery, preclinical and clinical stage compounds

  • Interact closely with the VP of Research and others to oversee planning, conduct and reporting of experiments performed in the lab

  • Serve as Study Director for advanced or specialized microbiology studies at the direction of the VP of Research. Duties here include test scheduling, test preparation, proper application of test method(s), data collection, data review, and approval of final report of analysis

  • Provide technical and scientific guidance to scientists working in the lab and the laboratory manager

  • Lead the development, implementation, and maintenance of systems, processes, and plans to ensure that results of experiments are delivered in a compliant manner, and within quality, cost and timeline parameters as agreed with the VP of Research

  • Develop long term strategic plan so that the lab functions at the highest level of quality, including the forecasting of resource, reagent, equipment and staffing needs to maintain the highest standards of scientific and technical excellence and efficiency in the laboratory

  • Ensure compliance with ContraFect laboratory SOPs, including those GMP SOPs, relevant to the conduct of laboratory work (e.g. the lytic assay) intended to support drug substance and drug product release and stability protocols for use in clinical and non-clinical trials.

  • Play a lead role in the development, review and approval of Laboratory SOP's, protocols, and reports

  • Maintain thorough knowledge and understanding of GLP and familiarity with GMP as relevant to work performed in lab on CF-301 drug substance and drug product release and stability protocols for use in clinical and non-clinical trials

  • Maintain working knowledge of current industry standards and practices pertaining to clinical microbiology), molecular biology, was well as protein biochemistry and protein engineering

  • Represent ContraFect externally to scientific experts, regulators, development partners and funding agencies as directed by the VP of Research

  • Contribute to the authorship of regulatory submissions (INDs, NDAs/BLAs, MAAs, etc.), as well as other documents such as Investigator Brochures, Microbiology manuals for clinical studies, IMPDs, and similar documents

  • Author scientific abstracts, manuscripts and reports. Present data at scientific meetings, and grant review meetings

  • Supervise, motivate, review, and develop direct reports through mentorship, training and identification of other learning opportunities

Education, Experience, Skills

  • A Ph.D. in microbiology, or a related field is required, with at least 5 years of post-graduate clinical microbiology experience in pharmaceutical or biotechnology setting or at a CRO

  • Extensive 'hands on' experience and knowledge in areas of microbiology (including the safe handling of bacterial pathogens)

  • Experience in successful management of a microbiology laboratory in an academic, industry or biotechnology setting or experience managing a CRO laboratory in relevant discipline (e.g. microbiology) required

  • Direct people management experience is preferred

  • Knowledge/experience in molecular biology and protein biochemistry, particularly designing, expressing and purifying recombinant proteins is a plus


  • Demonstrated the ability to carry out independent microbiology research through the design, conduct, and reporting of studies and a proven track record of publications and scientific presentations

  • A working knowledge of Good Laboratory Practice (GLP) and Good Documentation Practice (GDP) is required

  • Solid leadership skills required. Must be able to give directions clearly. Must be able to lead both by example and through direct instruction. Must be able to build consensus among a group of individuals. Good listening skills required. Must be able to actively elicit feedback from staff.

  • Excellent written and oral communication skills, including strong formal presentation and analytical skills

  • Ability to present complex microbologic data to a wide range of audiences including: internal project teams, academic experts/leaders in the field, grant reviewers, and development partners

  • Excellent people and project management skills

  • Ability and desire to successfully work with a collaborative, fastpaced project team in an entrepreneurial work environment

  • Ability to influence, negotiate and successfully communicate with both internal and external stakeholders

  • Excellent organizational, planning, and project management skills

Our Values:

Respect. People matter.

Patient- Focus. Act with urgency and passion to save lives.

Leadership. Set high standards, and empower others to do the same.

Innovation. Challenge the status quo to deliver solutions.

Collaboration. Work together to achieve our vision.

Quality. Strive for excellence in all that we do.

Integrity. Courage to be honest, ethical, and transparent.

Salary: Commensurate with experience.

No phone calls, please.

icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Assistant Director IT Project Management (Yonkers NY Us)


Posted 1 week ago

VIEW JOBS 11/9/2019 12:00:00 AM 2020-02-07T00:00 Montefiore Health System employs over 30,000 associates, including our IT division of 800 people focused on deploying technology, identifying process improvements, and using best IT practices to improve patient care. Across the Montefiore enterprise, all IT portfolios are managed by members of the Project Delivery Services team. The team is comprised of Portfolio Managers, who partner with department leaders to manage their portfolios of projects, and highly skilled Project Managers with expertise in Clinical, Business and Financial Systems, and Infrastructure initiatives. Project Managers accomplish their goals in a matrix setting which may include consultants, vendors, and other external resources.   We are seeking an Assistant Director for the Project Delivery Services team.   The Assistant Director is responsible for overseeing the delivery of portfolio management services and the delivery of technology solutions to fulfill business needs. The Assistant Director works closely with IT leadership and evaluates requests and proposals for new systems, enhancements, and other opportunities. The Assistant Director applies technical and business knowledge to provide departmental guidance. He/she is required to employ project management methodology in order to ensure the successful delivery of project-based work. The Assistant Director ensures the delivery of outstanding client service and contributes to the organization’s mission of utilizing information technology to improve patient care.   RESPONSIBILITIES INCLUDE:   * Oversee operational activities for the department. * Provide oversight to ensure the ongoing success of the departmental teams. * Administration of personnel and fiscal issues. * Act as a point person for any escalated issue regarding departmental activities. * Develop policies and procedures for department and coordinate with other Assistant Directors to ensure consistency across departments. * Manage other initiatives on behalf of Director, as required. * Build and manage teams of IT professionals and managers. * Ensure the delivery of excellent client service through effective teams. * Provide direction on departmental hiring. * Implement team building policies and concepts. * Responsible for performance management and the professional development of team members. * Ensure that employees are empowered to make decisions appropriate for their level and are meeting regularly with assigned manager on work goals and career development plans. * Responsible for the delivery of business and technical solutions. * Manage projects across the phases of design, development, implementation, and support. * Monitor the status and progress of projects and effectively communicate details to Director. * Oversee the response to requests for proposals from clients. * Develop appropriate performance metrics for project evaluation and acceptance.   * Act as a liaison between client and Montefiore IT. * Respond to client inquiries when management involvement is required. * Create policies to ensure a proactive approach to customer service. * Ensure performance metrics are at or above defined levels. * Work closely with other department management and stakeholders. * Collaborate on the development and implementation of best practices to align with the business objectives of Montefiore IT. * Oversee the resolution of strategic issues and systematic problems. * Coordinate with Client Executives and Project Managers to ensure customer satisfaction. * Analyze current business practices, processes, and procedures.  * Plan fr growth and future business needs and ensure the ability to effectively manage potential client business. * Provide direction to ensure that proposed solutions or service offerings meet customer requirements. * Perform complex problem and process analysis to develop creative solutions. * Perform other related duties as required.   REQUIREMENTS INCLUDE: * Significant experience in a leadership role in a corporate IT environment * Experience in managing a PMO * Expertise in best practices for project management * Budget and vendor management experience   DESIRED: * Experience in a health care delivery enterprise * Experience managing a complex business/financial systems portfolio, ideally in a heavily regulated, compliance-focused environment Department: Montefiore Information Technology Bargaining Unit: Non Union Campus: YONKERS Employment Status: Regular Full-Time Address: 3 Odell Plaza, Yonkers Shift: Day Scheduled Hours: 8:30 AM-5 PM Req ID: 106913 Montefiore is an equal employment opportunity employer. Montefiore will recruit, hire, train, transfer, promote, layoff and discharge associates in all job classifications without regard to their race, color, religion, creed, national origin, alienage or citizenship status, age, gender, actual or presumed disability, history of disability, sexual orientation, gender identity, gender expression, genetic predisposition or carrier status, pregnancy, military status, marital status, or partnership status, or any other characteristic protected by law. LI-SC1-REDIRECT Montefiore Yonkers NY

Director Of Clinical Microbiology

Contrafect Corporation