Director, Non-Clinical Operations

Alector, Inc. South San Francisco , CA 94080

Posted 5 months ago

At Alector, our mission is to develop therapies that empower the immune system to cure neurodegeneration. Our team is solely focused on developing cures for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and board members, leading healthcare investors and some of the most innovative pharma companies.

Would you like to take part in creating new therapies that really make a difference in patients' lives? Are you motivated by opportunities to make operations run smoothly? Do you derive satisfaction from anticipating and preventing issues that could derail outcomes or timelines? Would you like to be part of a talented team where everyone has a voice, and where innovation flourishes?

Use your hard-earned non-clinical operations, project management, and outsourced contractor management skills to help us achieve our mission of saving lives by curing neurodegenerative diseases.

As Director of Non-Clinical Operations for Alector, you'll closely collaborate with research biologists, assay development scientists, clinical scientists, regulatory and operations managers and the project team leaders. You will provide technical and operational support for the development of all Alector's products, which includes study design, protocol development in collaboration with functional representatives to support IND filing, and comprehensive CRO oversight. You'll be able to contribute across a variety of programs and have broad involvement in work central to Alector's strategic goals.

During the first year, your goals will include:

  • Oversee the development of toxicology package to support IND filing for multiple programs

  • Support multiple programs to conduct pharmacology and PK/PD studies at CROs with a good understanding of disease indication, MOA, clinical strategy, and target profile

  • Facilitate planning, development, tracking, and study timelines of nonclinical outsourced studies. Edits and reviews documents for consistency, completeness, and accuracy with minimal supervision

  • Collaborate closely with research teams and project teams, directly contribute to and represent non-clinical operations on internal and external project teams

  • Draft and review the Non-Clinical sections of new INDs and IBs

  • Demonstrates clear and concise verbal and written communication

  • Facilitates open communication across all departments

  • Possesses a solid understanding of GLP regulations, program science, and CRO landscape

We'd love to hear from you if:

  • You take pride in being persistent, self-motivated, and efficient

  • You thrive in an environment where we work independently and on teams

  • Bachelor's degree in life science or quality-related field and at least 8 years of experience in toxicology, pharmacology, pharmacokinetics, immunology, biological sciences or related discipline. MS or PhD preferred

  • You have hands-on experience with non-clinical toxicology studies to support regulatory filings

  • You possesses a solid understanding of GLP regulations, program science, and CRO landscape

  • You demonstrate a track record of managing relationships with vendors, suppliers, and contract organizations effectively

  • You have excellent communication skills, including the ability to influence cross-functionally and articulate complex issues clearly to drive understanding and decision-making

  • You have a point of view but are low ego

At Alector, we believe that high-performing teams include people from a wide variety of backgrounds and experiences who can challenge each other's assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.

Alector is a phenomenal place to learn and experiment. If you excel in a dynamic environment where everyone is committed to finding a cure, where you'll drive growth, this is the role for you. There is no limit to how far you can go with us.


While we've focused on what to look forward to during the first year and beyond, Day One is great, too: committed and driven colleagues, a bold and important company goal, state-of-the-art brand-new brightly-lit offices in the heart of the biotech area, competitive compensation and benefits. But these matter only if you're excited to build and own something great, and tackle these challenges with us. Come join us.

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Director, Non-Clinical Operations

Alector, Inc.