Director Myeloma Disease Lead Translational Medicine

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Bristol Myers Squibb is an integrated global biopharmaceutical company engaged primarily in the discovery, development, and commercialization of novel therapies in the areas of hematology/oncology, cardiovascular and inflammatory diseases through innovative small molecule, biologicals and cell therapy approaches.

BMS R&D is at a critical and exciting phase of development. As it expands and integrates its portfolio with recent and exciting new acquisitions, there is an opportunity for a science-driven, dynamic and ambitious individual to aid in leading our reverse translational efforts in multiple myeloma within our Hematology Translational Medicine Department at our site in Summit, New Jersey.

Translational Medicine is part of the Global Research and Early Development organization in BMS and leads mid- to late-stage clinical, pharmacological, and translational research and development activities for the BMS hematology pipeline. The Translational Medicine team supports the late-stage portfolio for regulatory, translational development and life cycle management. Translational Medicine Hematology at BMS has a long-standing history of scientific rigor as evidenced by our peer-reviewed publications, delivery of drug approvals including Revlimid, Pomalyst, Idhifa, Inrebic, Onureg and Reblozyl, strong academic collaborations and talent development. Our areas of focus include but are not limited to multiple myeloma, acute myeloid leukemia/MDS, lymphoma and erythroid disorders. This group integrates scientific learnings from the lab and clinic as well as business insights of multiple functions and leads the development of translational strategies at the franchise level.

Reporting to the VP, Hematology Translational Medicine Disease Team (TMDT), the incumbent will be responsible for development and execution of disease-centric translational strategies in multiple myeloma to maintain a leadership position for BMS in this key disease area in the future. An experienced scientist/strategist is needed to lead the disease work in multiple myeloma who has the ability to anticipate and adapt to the evolution of clinical practice where molecular segmentation and routine assessment of measurable residual disease (MRD) will likely become critical to patient management and drug development. Additionally, this individual will maintain strong relationships with key physician-scientists in myeloma to collaborate on high priority questions/research projects to inform cutting-edge above-asset and asset strategy for BMS as treatment landscapes and scientific knowledge of the disease advance. Key responsibilities of this role are to act as the lead multiple myeloma disease scientist to improve understanding of disease biology and high-risk disease, deliver patient selection strategies, develop data to support combination strategies and life-cycle management for our pipeline. Individual will manage strategic disease collaborations and projects with external experts in myeloma. In addition, this individual will work on cross-functional project teams to drive execution of translational strategies, including application of MRD in myeloma, through collaboration with laboratory and computational scientists as well as BMS members from clinical, commercial, regulatory and diagnostics as well as external academic collaborators.

The starting compensation for this job is a range from $194,000 - $244,000, plus incentive cash and stock opportunities (based on eligibility).The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/

Technical Skills

• In-depth understanding of multiple myeloma disease, the evolving diagnostic, treatment, clinical development and reimbursement landscape and competitive scenarios

• Strong relationships with multiple myeloma physician-scientist KOLs at key institutions in USA and Europe

• In-depth understanding of molecular patient segmentation and application of MRD in multiple myeloma

• Strong understanding of clinical, translational, and mechanistic data of current myeloma therapies in both NDMM and RRMM, including, IMiDs, CELMoDs and immune redirecting therapies.

• Strong background in strategy development

• Background in tumor genomics and/or single cell analysis

• Understanding of late-stage drug and translational development process

• Proven ability to work with global disease teams to develop strategies to support life cycle management efforts tailored to regional markets (i.e, US, EU, CAN)

• Strong verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications/reviews, disease strategies, mechanism slides, regulatory submissions, strategic communications, literature/market/pt segment analyses

• Proven scientific/project leadership expertise (working in teams, managing people/projects)

• Ability to synthesize complex scientific and business problems into strategy and tactics

• Basic understanding of IP, contracting terms and provisions

Responsibilities

Strategy Role

• Lead the long-term disease strategy goals and objectives in multiple myeloma by working with MM asset leads and project managers and taking ownership of myeloma disease goals

• Lead multiple myeloma above asset genomics/immune internal and external projects (eg, external collaborations, identification of high-risk disease and patient segments) including establishing new collaborations and strategic partnerships with key KOLs and Institutions

• Represent TM in cross-functional Strategy and Disease-oriented Global Project Teams (such as MRD)

• Support efforts to implement molecular profiling and routine MRD assessment efforts in multiple myeloma internally and externally

• Interface with Commercial including early commercialization group, Global Drug Development, and Medical Affairs to provide scientific support for cross-functional TM goals

• Lead the communication strategy for the multiple myeloma disease team including regulatory submissions, lead and manage the development of key publications internally and with collaborators

Development Role

• Participates in development of pipeline differentiation strategy (such as CELMoDs, sequencing of BCMA therapies)

• Leads the development of myeloma above-asset translational annual goals and objectives and is accountable for their execution in association with TM scientists

• Participates in translational research from the Hematology Laboratory

• Attend and represent Heme TM at other forums as needed to support the Myeloma Disease Head

• Assists in developing and maintaining multiple myeloma budget for above asset collaborations/projects

Communication Role

• Communicates regularly and prepares and makes presentations within the department and externally as required

• Leads development of abstracts/posters/manuscripts in multiple myeloma in conjunction with TM scientists and collaborators

• Participates or run scientific advisory boards to support drug and disease programs/projects

• Oversees publication plans and writing for Hematology TM Disease Team in conjunction with TM writers and Myeloma Program Manager, including manuscripts, congress submissions, regulatory submissions

Basic Qualifications:

• Bachelor's Degree
• 15+ years of academic and / or industry experience

Or

• Master's Degree
• 12+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

• 8+ years of academic and / or industry experience

• 6+ years of leadership experience

Preferred Qualifications:

• PhD in Hematology/Oncology or related field with 10 years in industry or an academic setting

• Track record of success in large and small companies, leading innovative efforts to deploy technologies and assays for enhanced translational capabilities

• Proven track record of success in drug discovery and development

• Excellent communication, managerial and scientific qualities are expected

• Ability to interact effectively across boundaries using influencing and relationship building skills

• Competence in analysis and solving of problems, and the ability to prioritize and make tradeoffs to achieve goals

Other Attributes

• A problem solver who creatively and knowledgably transcends departmental function to act as a resource to entire research effort and senior managers in development

• Identifies issues early and proposes innovative solutions

• Communicates within the larger organization and external community

• Provides expert guidance to multi-disciplinary teams and senior management

• A leader whose scope of influence stretches across BMS as well as the external scientific community in multiple myeloma

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as "Transforming patients' lives through science ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

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