Director, Bioinformatics & Data Science

Twist Bioscience Corporation South San Francisco , CA 94080

Posted 2 months ago

Programmable DNA, the software of Life, is finally here! Twist Bioscience is developing a disruptive Synthetic DNA technology that will change the world, enabling widespread health and sustainability. Synthetic biologists will use our products to engineer how organisms produce cures to diseases, make everyday chemicals by using the atmosphere as the carbon source, enable plants to make their own fertilizers, and to create in-vivo diagnostics that alert us when we are sick, and many more applications.

We are seeking a highly-motivated, technical leader to serve as the Director of Bioinformatics/Data Science who will play a key role in leading the development of novel algorithms and all analytical aspects of our machine-learning based synthetic DNA products. With a combination of excellent leadership and technical knowledge in bioinformatics and data functions, this individual will guide our teams of bioinformaticians and data science in the development of novel algorithms and pipelines to design, sequence, and analyze synthetic DNA for a variety of product lines and applications. The individual's responsibilities will span R&D work in algorithms, product development, and the implementation of production-ready, scalable and robust pipelines, with a strong emphasis on NGS sequencing and genomics. For data science, the individual will manage ML model generation and deployment, MLOps, data engineering and warehousing, and reporting/BI. The ideal candidate will have a deep understanding of molecular biology techniques, especially as they relate to DNA, and a wide breadth of knowledge and experience in NGS sequencing, bioinformatics tools, building models and infrastructure from scratch, and a proven track record of creating business value by deploying ML models to production in a scalable fashion.

This position will report to the SVP, Operations and will work closely with diverse functions across the entire organization to ensure that our different verticals have the bioinformatics and data science support that they need, including Molecular Biology R&D, Operations, Pharma, software engineering, eCommerce, and others. The individual will provide matrixed support and deep technical and scientific guidance to other departments. The individual will also guide the strategy and execution of our scientific computing roadmap.

A deep understanding of sequencing technologies, target enrichment, genomics, and molecular techniques is highly preferred. Strong communications and interpersonal skills are absolutely required.

Responsibilities

  • Attract and maintain a team of the highest caliber bioinformatics and data science talent

  • Develop new computational methods and pipelines to characterize DNA-based products such as genes, oligo pools, target enrichment panels, and variant libraries

  • Build and deploy robust, scalable, internally- and externally-facing bioinformatics pipelines

  • Partner with stakeholders in other departments to execute collaborative projects

  • Develop and execute a bioinformatics and data strategy in collaboration with senior leadership

  • Communicate effectively to all levels of the organization, including executives

  • Manage our computational biology codebase

  • Manage our bioinformatics infrastructure

  • Build and deploy machine learning models into production

  • Develop new methods and data to answer deep questions in operations, marketing, and beyond

Required Experience:

  • Ph.D. (or equivalent experience) in computational biology, bioinformatics, genomics, systems biology, statistical genetics or a related field

  • 7+ years of industry experience in bioinformatics, both as an individual contributor and managing teams

  • Strong programming skills, with a preference for Python

  • Experience with workflow management tools (Luigi, Airflow, etc.)

  • Proven track record of developing custom algorithms for NGS sequencing analysis or related problems

  • Experience working with genomics data sets

  • Track record of attracting and retaining top talent, and managing effective computational biology and data science teams

  • Experience designing a bioinformatics and data science roadmap and executing the vision behind it

  • Track record of working effectively in cross-functional projects

  • Technical knowledge of molecular biology techniques and bioinformatics, with an emphasis on NGS sequencing, target enrichment, and/or genomics

  • Strong communication and interpersonal skills

Preferred Experience

  • Experience with Kubernetes and CI/CD

  • Broad understanding of AWS resources and experience using them

  • Familiarity with Databricks, MLflow, Spark and Seven Bridges

  • Exposure to the drug development process, IVD, of PGx

  • Experience with ML deployment frameworks (Sagemaker, Kubeflow, etc.)

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as "writing" DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

San Francisco applicants: Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.


icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Senior Director / Vice President Translational Science

Neuron23, Inc.

Posted 6 days ago

VIEW JOBS 5/28/2020 12:00:00 AM 2020-08-26T00:00 <p>Neuron23, Inc. is a venture-backed stealth-mode company in South San Francisco working on small molecule therapeutics for the treatment of Neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. The company has a strong pipeline of molecules against genetically-validated known and novel targets and expects to enter the clinic with its lead program in Q4 2020.</p><p>We are seeking a Senior Director / VP, Translational Sciences to lead Neuron23’s late preclinical/early development activities and to play a pivotal role in advancing the company’s overall R&amp;D strategy. We are looking an individual to join our enthusiastic and energetic team in taking on the development of therapies for grievous genetic disorders. The Translational Sciences Team Leader will participate in efforts to bring innovative drug candidates to approval. The successful candidate will lead product Translational Sciences teams (composed of matrixed individuals internally, consultants or CROs) to develop and execute on the Translational Sciences strategy to enable drug development candidates to move through clinical development. The successful candidate will also work and communicate with project team members from many disciplines outside of Translational Sciences, such as Clinical Development, Regulatory, and Drug Safety. Keys for success will include effective leadership of cross-functional teams; reviewing and integrating project data from Translational Sciences efforts; communicating data and program impacts to key stakeholders and project teams; and developing and mentoring Translational Sciences teams. The successful candidate will also be part of a vibrant and experienced research and development team driving the scientific understanding, development, and registration of novel therapeutics in a company dedicated to finding cures to grievous disease. The successful candidate will be expected to have a significant degree of autonomy, act as a delegate for senior management roles, and be a key individual in department leadership succession plans. The candidate is expected to model and inspire a strong collaborative and can-do attitude across the different functions of the company as an individual team leader and as a senior management team member. The Senior Director / VP, Translational Sciences will report to our Chief Scientific Officer.</p><p><strong>Key Responsibilities:</strong></p><ul> <li>Provide cross-functional leadership to initiate and lead cutting edge research on and the application of small molecule therapeutics</li> <li>Develop and execute research and early project plans that will systematically address multiple target and indication opportunities</li> <li>A keen interest in neuroscience and immunology is required</li> <li>Create and execute overall translational plan to ensure robust, cost-effective support of company discovery and development portfolio</li> <li>Maintain the highest level of scientific rigor and professionalism within our organization</li> <li>Develop CSF and peripheral biomarkers</li> <li>Experience in PET development is an advantage</li> <li>Ability to pursue patient stratification approaches including use of genetics</li> <li>Support the CSO in planning discovery and translational activities including internal and external projects</li> <li>Develop accurate budget and staff projections to support multidisciplinary team goals</li> <li>Recruit high-quality personnel to support translational plan; internal and external</li> <li>Evaluate and select CROs and CMOs to support key preclinical and clinical activities</li> </ul><p><strong>Requirements</strong></p><ul> <li>MD/PhD, MD with training in neurology and a strong background in preclinical research, or PhD with significant development and early clinical leadership experience</li> <li>15+ years’ experience in the life sciences with at least 10+ years’ industry experience in small molecule therapeutics, including exposure to preclinical and clinical development activities; ideally having driven multiple translational programs successfully into clinical studies</li> <li>Demonstrated success in the design, medicinal chemical optimization, and formulation/delivery of small molecule therapeutics</li> <li>Demonstrable experience with successful IND and/or NDA submission or equivalent is preferred</li> <li>Experience in young rapidly growing companies is strongly preferred</li> <li>High degree of energy, attention to detail, and a passion for delivering important new therapies to patients with devastating diseases</li> <li>Outstanding scientific leadership, collaboration, and management skills with an integrated view of business and scientific issues</li> <li>Excellent verbal and written communication skills. Ability to interact with staff (at all levels) productively in a fast-paced environment</li> <li>High degree of energy, attention to detail, and a passion for delivering </li> </ul><p>Neuron23 is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital &amp; veteran status. </p> Neuron23, Inc. South San Francisco CA

Director, Bioinformatics & Data Science

Twist Bioscience Corporation