Cryo-Electron Microscopy Scientist

Stanford University Stanford , CA 94305

Posted 3 months ago

Stanford School of Medicine is seeking a cryo-EM scientist to support the operation of our expanding, state-of-the-art electron microscopy facility. The facility includes 2 Titan Krios and 1 Tecnai F20 microscopes for single particle and tomography studies. This team member, along with others, will be responsible for oversight and maintenance of these microscopes as well as training and assisting users. The cryo-EM specialist will have ample opportunities to advance and grow professionally within our research environment, which includes the scientific communities at both Stanford and SLAC.

We are looking for a colleague who will be excited about interacting with researchers at all levels and will consistently strive to maintain a state-of-the-art facility. This EM scientist will join a team of two others to support our new cryo-EM initiative. This job is an excellent opportunity for an electron microscopist interested in joining the Stanford/SLAC community.

Duties include:

  • Interface and collaborate with High Performance Computing team, who will assist with computational needs for optimal data collection, storage and data processing.

  • Interface and collaborate with Microscopy Core, which houses electron microscopes for preliminary screening of samples Maintain FEI Tecnai F20 and Krios microscopes. This duty requires interfacing with FEI engineers to ensure optimal performance of the microscopes.

  • Maintain ancillary, cryo-EM related equipment such as Vitrobot, glow discharger etc.

  • Load samples and tune microscopes prior to data collection.

  • Train and oversee users for data collection.

  • Evaluate quality of data obtained by users.

  • Implement data collection strategies that will benefit our user community.

  • Maintain accurate logs for microscope performance and usage.

    • Other duties may also be assigned

DESIRED QUALIFICATIONS:

  • Ph.D. in same field with 2 years of cryo-EM experience

  • BA or MA in structural biology, biochemistry, bioengineering or related field plus 5 years of related experience; or At least 2-5 years of cryo-EM experience, with expertise in handling samples, using microscopes and evaluating data.

  • Excellent communication and interpersonal skills.

  • Solid understanding of the principles of transmission electron microscopy.

  • Best practice knowledge of computational image processing and analysis of cryo-EM images.

  • General understanding of single particle cryo-EM workflow; experience in cryo electron tomography is a plus.

EDUCATION & EXPERIENCE (REQUIRED):

Associate degree or certificate of completion in a related engineering or related scientific discipline, or three to four years of equivalent work experience.

KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):

  • Experience applying scientific and engineering principles and practices to perform technical services and support.

  • Experience with data analysis, experimental process, design, and development of prototypes, equipment, and/or systems related to area of specialization.

  • Ability to write clear documentation, perform administrative duties, and research protocol maintenance related to research studies and/or scientific/engineering projects.

  • Experience with software applications, systems, or programs relevant for the job.

  • Ability to interpret and determine validity of data and check own work.

  • Ability to communicate, liaise, and work with staff, students, faculty, and outside vendors.

  • Ability to effectively supervise and train a diverse work staff.

CERTIFICATIONS & LICENSES:

None

PHYSICAL REQUIREMENTS*:

  • Frequently grasp lightly/fine manipulation, perform desk-based computer tasks, lift/carry/push/pull objects that weigh up to 10 pounds.

  • Occasionally stand/walk, sit, twist/bend/stoop/squat, grasp forcefully.

  • Rarely kneel/crawl, climb (ladders, scaffolds, or other), reach/work above shoulders, use a telephone, writing by hand, sort/file paperwork or parts, operate foot and/or hand controls, lift/carry/push/pull objects that weigh >40 pounds.

    • Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

WORKING CONDITIONS:

  • May be exposed to high voltage electricity, radiation or electromagnetic fields, lasers, noise > 80dB TWA, Allergens/Biohazards/Chemicals /Asbestos, confined spaces, working at heights ?10 feet, temperature extremes, heavy metals, unusual work hours or routine overtime and/or inclement weather.

  • May require travel.

Additional Information

  • Schedule: Full-time

  • Job Code: 4103

  • Employee Status: Regular

  • Grade: H99

  • Requisition ID: 85375

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Cryo-Electron Microscopy Scientist

Stanford University