Contractor, Research Associate II, Cryoem Lab

About Generate Biomedicines

Generate:Biomedicines is a new kind of therapeutics company - existing at the intersection of machine learning, biological engineering, and medicine - pioneering Generative Biology to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received over $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300+ employees.

The Role:

Generate Biomedicines is seeking a Contractor, Research Associate II to join our CryoEM Group in generating large-scale protein structural datasets. This role offers the opportunity to work at the intersection of protein biochemistry and cutting-edge structural biology, contributing to our mission of accelerating drug discovery through advanced imaging technologies. This is a full time Contractor role through 12/19/2025.

Here's How You Will Contribute

• Perform protein purification, complexation, vitrification, and clipping, ensuring high-quality sample preparation for CryoEM.
• Load and operate CryoEM microscopes, executing data collection with automated workflows.
• Collaborate with multidisciplinary teams to support high-throughput protein structure determination.
• Follow standard operating procedures (SOPs) and contribute to process optimization.
• Document experimental data and report findings in internal databases.

The Ideal Candidate Will Have

• MSc in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Chemistry, or a related field and 0-2 years of experience, or a BSc in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Chemistry, or a related field with 2-4 years of related experience. We are also open to Research Associate I level talent with a BSc in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Chemistry, or a related field with 0-2 years of related experience.
• Hands-on experience in basic wet lab techniques, including pipetting, buffer preparation, and protein purification.
• Strong understanding of protein chemistry concepts, such as molarity, protein concentration, and buffer formulation.
• Ability to work in a fast-paced, collaborative research environment.
• Strong attention to detail and ability to troubleshoot technical issues.

Preferred Additional Skills

• Familiarity with structural biology techniques and CryoEM sample preparation.
• Hands-on experience with liquid handlers (Tecan, Hamilton).
• Prior exposure to CryoEM workflows or microscope operation with SerialEM.

This role will be based in our CryoEM lab in Andover, MA

If you're excited about applying your skills to protein structure determination and working with state-of-the-art CryoEM technologies, we encourage you to apply!

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

COVID Safety:

Generate:Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster. The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations. The Company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

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