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Computational Biologist -- Host-Microbe Immunity

Expired Job

Glaxosmithkline Collegeville , PA 19426

Posted 3 months ago

Your Responsibilities:

The Computational Biology Department supports Drug Discovery and Development at GSK Pharmaceuticals R&D through the integrative analysis of internal and external biomedical data. Our analysis competencies are quite diverse and include target identification and validation, genetics, pathways and networks, disease indications, text mining, molecular evolution, gene expression, microbiome/host pathogen analysis, drug repositioning and machine learning. We contribute to multiple phases of the drug development pipeline and our work results in developing new medicines for important diseases of unmet medical need.

We are hiring a skilled Computational Biologist to focus on host-microbe immunity research which includes infectious disease, host-pathogen interactions and the microbiome. In the pharmaceutical industry, GSK is world leader in the development of medicines against the most severe infectious diseases including HIV, hepatitis B virus, bacterial infections, TB, malaria and other parasites. GSK is also a microbiome research innovator in various therapy areas including respiratory and inflammatory diseases.

Applicants should have a strong background in the areas of bioinformatics, computational biology, computer science and/or genomics with preferred experience in one or more of the host-microbe immunity research areas. You should be comfortable working in a dynamic and highly collaborative environment, and be expected to communicate and interpret complex informatics analyses and results to scientists from diverse backgrounds.

Furthermore, you will be encouraged to develop and advance your career skills as well as your internal and external scientific profile through presentations and peer-reviewed publications. GSK offers excellent work-life balance for its employees and is an equal opportunity employer.

Why You?Basic qualifications:

  • PhD in computational biology, bioinformatics, and/or biomedical/biological sciences with an emphasize on data analytics.

  • Strong written and oral communication skills.

  • Ability to work effectively in multidisciplinary teams.

  • Publication record in peer reviewed journals.

Preferred qualifications:

  • Expertise in applying genome-wide genetic, genomic, pathway and network methods to host-microbe immunity questions including pathogen genomics, host-pathogen interactions and the microbiome.

  • Expertise in a programming language (such as R, Python or Perl) for complex data analysis.

  • Knowledge of and experience with common bioinformatics databases, resources and tools.

  • Demonstrated experience in processing multiple large scale genomic and genetic platforms, such as transcriptomic, proteomic or Next Generation Sequencing data.

Why GSK?:

Some examples of recent publications by GSK Computational Biology:
1.Wang Z, et al. 2018. Meta-analysis of human gene expression in response to Mycobacterium tuberculosis infection reveals potential therapeutic targets. BMC Systems Biology. 12:3 DOI 10.1186/s12918-017-0524-z
2.Wang Z, et al 2016. Lung microbiome dynamics in chronic obstructive pulmonary disease exacerbations. European Respiratory Journal. 47:1082.
3.Saha S, et al. 2016. Human microbial metabolites as a source of new drugs. Drug Discovery Today. 21: 692.
4.Arat S, et al. 2015. Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase. Antimicrobial Agents and Chemotherapy. 59:1182.
5.Rajpal D, et al. 2015. Selective spectrum antibiotic modulation of the gut microbiome in obesity and diabetes rodent models. PLoS One. 10: e0145499.
6.Pea I, et al. 2015. New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: An open resource. Scientific Reports (Nature). 5:8771.
7.Gamo F-J, et al. 2010. Thousands of chemical starting points for antimalarial lead identification. Nature. 465:305-310.

Contact information:

You may apply for this position online by selecting the Apply now button.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK HR Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK.

The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.



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Computational Biologist -- Host-Microbe Immunity

Expired Job

Glaxosmithkline