Glaxosmithkline Collegeville , PA 19426
The Discovery Biology Automation team is designing an intelligent, automated platform to accelerate the identification of high value small molecule leads using human complex in vitro models. The use of relevant in vitro models to screen for potential therapeutic targets has already been shown to reduce the attrition rate that the pharmaceutical industry has been struggling with.
To achieve human pharmacology for discovery leads, our group is engaging in multidisciplinary collaborations to develop novel preclinical models and cell-based screening technologies to improve clinical relevance. Specifically, we are seeking a highly productive cell biology scientist that can design and execute experiments efficiently, and interpret data in the context of multidisciplinary project teams. There is also a need to develop cell complex stem cell derived in vitro disease models as well as cell-based microfluidic systems and biomaterial scaffolds.
The successful individual will be responsible for drawing upon experience and collaborating with internal experts to automate medium to high throughput assays for pipeline support. In these uncharted territories, this individual will need to be inquisitive, creative and bold.
Develop assays in biochemical and cell based formats that are suitable for automated high-throughput screening in 384 or 1536-well formats
Analyze and prepare screening data for presentation at program team meetings
Develop innovative approaches for screening and hit triage
Responsible for design, planning, conduct and troubleshooting of multiple experiments to ensure high data quality
Identify, develop, optimize and validation of new phenotypic screening assays and their transfer to automated systems for high throughput screening
Develop and effectively apply a broad spectrum of practical laboratory skills
Contribute to the overall scientific knowledge and skill level of the group through interacting with group member at all levels
Independently author scientific papers and presentations, and help represent the team and GlaxoSmithKline at internal and external scientific meetings
Mentor associate scientists to accomplish any of the above tasks
Why You?Basic qualifications:
PhD in Cell Biology or a Life Science with 0-2 years postgraduate experience or a Masters in the same with 3-6 years postgraduate experience
Strong background in developing complex in vitro cell models such as spheroids, organoids or organs-on-a-chip and familiarity with automation
Deep understanding of pluripotent (eg. hESC and hiPSC) cell culture, primary cells and routine cell lines
Proficiency in molecular techniques such as gene editing, gene delivery, RNA silencing adapted for primary cells and pluripotent stem cells
Demonstrated expertise in various assay methodologies including protein-protein interaction readouts (e.g. AlphaLISA and FRET/BRET assays), MSD and image-based high content screening
Collaborative and able to work in a team-oriented, matrix environment
PhD in Cell Biology or a Life Science
Demonstrated understanding of drug discovery and familiarity with integrated automation systems, such as those employed in High Throughput Screening in the Pharmaceutical industry
Job Description Summary-Are you inquisitive? Creative? Bold? GlaxoSmithKline is a science-led global healthcare company that researches and develops a broad range of innovative products in the areas of Pharmaceuticals, Vaccines and Consumer Healthcare, and we need individuals like you to join us in disrupting Healthcare. Together, with a newly formed team of diverse and multi-disciplinary scientists, you will help us create new Intelligent and Automated platforms that will help the company rapidly discover and develop novel medicines to help patients do more, feel better and live longer.
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