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Cell Biologist, Discovery Biology Automation

Expired Job

Glaxosmithkline Collegeville , PA 19426

Posted 5 months ago

Your Responsibilities:

The Discovery Biology Automation team is designing an intelligent, automated platform to accelerate the identification of high value small molecule leads using human complex in vitro models. The use of relevant in vitro models to screen for potential therapeutic targets has already been shown to reduce the attrition rate that the pharmaceutical industry has been struggling with.

To achieve human pharmacology for discovery leads, our group is engaging in multidisciplinary collaborations to develop novel preclinical models and cell-based screening technologies to improve clinical relevance. Specifically, we are seeking a highly productive cell biology scientist that can design and execute experiments efficiently, and interpret data in the context of multidisciplinary project teams. There is also a need to develop cell complex stem cell derived in vitro disease models as well as cell-based microfluidic systems and biomaterial scaffolds.

The successful individual will be responsible for drawing upon experience and collaborating with internal experts to automate medium to high throughput assays for pipeline support. In these uncharted territories, this individual will need to be inquisitive, creative and bold.

Key Responsibilities:

Develop assays in biochemical and cell based formats that are suitable for automated high-throughput screening in 384 or 1536-well formats

Analyze and prepare screening data for presentation at program team meetings

Develop innovative approaches for screening and hit triage

Responsible for design, planning, conduct and troubleshooting of multiple experiments to ensure high data quality

Identify, develop, optimize and validation of new phenotypic screening assays and their transfer to automated systems for high throughput screening

Develop and effectively apply a broad spectrum of practical laboratory skills

Contribute to the overall scientific knowledge and skill level of the group through interacting with group member at all levels

Independently author scientific papers and presentations, and help represent the team and GlaxoSmithKline at internal and external scientific meetings

Mentor associate scientists to accomplish any of the above tasks

Why You?Basic qualifications:

  • PhD in Cell Biology or a Life Science with 0-2 years postgraduate experience or a Masters in the same with 3-6 years postgraduate experience

  • Strong background in developing complex in vitro cell models such as spheroids, organoids or organs-on-a-chip and familiarity with automation

  • Deep understanding of pluripotent (eg. hESC and hiPSC) cell culture, primary cells and routine cell lines

  • Proficiency in molecular techniques such as gene editing, gene delivery, RNA silencing adapted for primary cells and pluripotent stem cells

  • Demonstrated expertise in various assay methodologies including protein-protein interaction readouts (e.g. AlphaLISA and FRET/BRET assays), MSD and image-based high content screening

  • Collaborative and able to work in a team-oriented, matrix environment

Preferred qualifications:

  • PhD in Cell Biology or a Life Science

  • Demonstrated understanding of drug discovery and familiarity with integrated automation systems, such as those employed in High Throughput Screening in the Pharmaceutical industry

Why GSK?:

Job Description Summary-Are you inquisitive? Creative? Bold? GlaxoSmithKline is a science-led global healthcare company that researches and develops a broad range of innovative products in the areas of Pharmaceuticals, Vaccines and Consumer Healthcare, and we need individuals like you to join us in disrupting Healthcare. Together, with a newly formed team of diverse and multi-disciplinary scientists, you will help us create new Intelligent and Automated platforms that will help the company rapidly discover and develop novel medicines to help patients do more, feel better and live longer.

Contact information:

You may apply for this position online by selecting the Apply now button.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK HR Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK.

The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.



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Cell Biologist, Discovery Biology Automation

Expired Job

Glaxosmithkline