Bioprocess Development Research Associate III

Bioprocess Development Research Associate III

Department: 48 - Bioprocess Development

Employment Type: Full Time

Location: Redwood City, CA

Description

Codexis, a biotechnology company based in Redwood City, CA, is looking to hire a Bioprocess Development Research Associate III.

Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver technology platform to discover, develop and enhance novel, high-performance enzymes and other classes of proteins. Codexis enzymes solve for real-world challenges associated with small molecule pharmaceuticals manufacturing and nucleic acid synthesis. The Company is currently developing its proprietary ECO Synthesis platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. Codexis enzymes can drive improvements, such as higher yields, reduced energy usage and waste generation, improve efficiency in manufacturing and greater sensitivity in genomic and diagnostic applications.

To meet the goals we've set for ourselves, we look for individuals who are driven, eager to grow and ready to embrace meaningful challenges. We empower employees to be authentic, ambitious, agile and have the courage to take action where they can make a positive impact.

Come join us on this journey to transform the enzyme engineering landscape for the betterment of human health.

About the Opportunity:

The Research Associate III is a part of the Downstream Bioprocess Development department and responsible for designing, performing, and analyzing experiments to establish, understand, and optimize enzyme purification processes. The Research Associate will also be responsible for communicating technical data and contributing to tech transfer activities for external manufacturing of cutting-edge enzymes for nucleic acid synthesis. This position will be based in Redwood City.

If any of the below describes you, we would love to meet you!

• Experience with protein purification and analysis, including chromatography, bioprocess filtration (depth filtration, TFF), and scale-up.

• Excellent interpersonal and communication skills to effectively communicate results and seek assistance when needed.

• Strong attention to detail and ability to keep organized records and documentation.

• A collaborative and safety-first mindset in a lab environment.

In this role you will be responsible for:

• Hands-on protein purification and downstream process development at scales from 0.1-50 L.

• Primary recovery unit operations from microbial hosts such as centrifugation, homogenization, flocculation, tangential-flow filtration, and depth filtration.

• Chromatographic separations, including ion-exchange, affinity, and hydrophobic interaction using AKTA Avant and Pilot systems.

• Unit operation optimization, scale-up, and support for tech transfer workflows.

• Characterizing in-process and purified proteins to support process development, including SDS-PAGE, UV-Vis, colorimetric assays, HPLC, SEC-MALS, DLS, etc.

• Working with a scientific mentor to execute planned experiments and document results.

• Designing experiments, thorough documentation (electronic lab notebook and batch production records), organizing data, and communicating results within the bioprocess development team.

The essential requirements of the job include:

• Bachelor's degree in Biochemistry, Biological Science, Chemical or Biomolecular Engineering, or related discipline, with 3+ years industry experience in hands-on protein purification and analysis, OR Master's degree with 0-3 years industry experience.

• Hands-on experience with chromatographic protein purification (e.g. affinity, ion exchange, hydrophobic interaction) using AKTA or other FPLC systems.

• Strong understanding of protein biochemistry as it applies to purification and enzyme characterization.

• Experience characterizing proteins using analytical methods such as activity assays, SDS-PAGE, HPLC, DLS, etc.

Additional experience that would be valuable for this role includes:

• Hands-on experience with protein recovery from microbial hosts, bioprocess filtration (e.g. TFF, depth filtration), flocculation, and/or non-chromatographic separations.

• Experience with high-throughput purification and/or analytical methods (including Design of Experiments).

• Experience with lyophilization and/or spray dry process development.

CODEXIS PAY TRANSPARENCY: The anticipated salary range for candidates who will work in Redwood City is $92,250 to $112,500. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. Codexis is a multi-state employer, and this salary range may not reflect positions that work in other states.

What can Codexis offer you?

• Medical, Dental and Vision Insurance

• Basic Life, AD&D, Short- and Long-Term Disability Insurance

• 401k with Company Match up to 4%

• Company Equity

• Generous Paid Time Off including 18 Company Holidays (with a summer and winter shutdown), Vacation, and Wellness Time

• Annual Lifestyle Account for reimbursement of fitness programs, equipment and more

• Employee Stock Purchase Program (ESPP)

• Flexible Spending Accounts (Commuter/Parking, Dependent Care & Healthcare)

• Student Debt Program (Company Contribution to Loans)

• Mental Health Wellness Program

• Subsidized onsite lunch program

• Onsite Gym Facilities

• Paid Parental Leave

• And More!