Bioprocess Analytical Chemist

Eurofins Scient. Chesterfield , MO 63005

Posted 1 week ago

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate.

Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies.

In over just 30 years, Eurofins has grown from one laboratory in Nantes, France to over 47,000 staff across a network of more than 900 independent companies in over 50 countries and operating more than 800 laboratories. Eurofins offers a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products, as well as providing innovative clinical diagnostic testing services, as one of the leading global emerging players in specialised clinical diagnostics testing.

In 2019, Eurofins generated total revenues of EUR 4.56 billion, and has been among the best performing stocks in Europe over the past 20 years.

Job Description:

The successful candidate will lead analytical assay support for the Upstream Process Development (UPD) and Purification Process Development (PPD) groups, based in Chesterfield, MO.

The Upstream Process Development (UPD) group is responsible for developing robust processes for cell lines producing the protein therapeutics. These are proteins that are chosen by research units as the candidate molecules for the treatment of various medical conditions spread across oncology, neuroscience, inflammation and many others. The processes developed by the UPD group are used in GMP manufacturing facilities to produce the molecules in large quantities for clinical and commercial needs.

One of the vital components of upstream process development is controlling the metabolism of the cells in culture. CHO cells consume large amounts of nutrients including amino acids and other metabolites to produce molecules of interest as well other byproducts.

Quantification of amino acids in the culture medium, protein concentration, as well as several other metabolites and byproducts are key to building robust processes and ensuring product quality. The successful candidate will drive the analytical support for the team by performing analytical testing on culture samples.

The Purification Process Development (PPD) group is responsible for developing robust purification processes that recover the protein therapeutic from the (above) culture medium. Typical technologies include liquid/solids separations via centrifugation, depth and membrane filtration, ultrafiltration, and chromatography.

As with upstream, significant in-process analyses and characterization are required in developing, scaling and optimizing the large scale GMP manufacturing processes. The successful candidate will drive the analytical support to the team by performing analytical testing on purification samples.


Job Responsibilities and Requirements:

The successful candidate will drive analytical support efforts for the UDP and PPD process development groups - receiving and managing samples, performing required analytical tests, processing the data and providing data summaries back to the responsible scientists.

For UPD group support, the successful candidate will preferably have hands-on experience or at least a basic knowledge of various analytical, cell culture and molecular biology techniques including but not limited to amino acid analysis using UPLC, titer assay using HPLC, and metabolite analysis using BioHT.

For PPD group support, the successful candidate will preferably have hands-on experience or at least a basic knowledge and aptitude for relevant analytical and wet chemistry techniques including but not limited to analytical chromatography via UPLC/HPLC (using size-exclusion, ion-exchange, reversed-phase, and/or affinity methodologies), spectrophotometry, host cell protein (HCP) analysis via ELISA and/or Gyros methodologies, Caliper/CGE, SDS-PAGE.

General requirements include performing data analysis using Microsoft Excel, composing scientific documents for electronic lab notebooks, and maintenance of experimental data in relevant electronic databases. Strong organizational skills and a readiness to support a safe working environment are also required.

A working knowledge of Empower control and data analysis software is strongly preferred, as well as a willingness to interact with external vendors and/or internal site operations to solve instrument and/or facility issues.

Additional responsibilities may include routine maintenance on UPLC/HPLC, calibrations, troubleshooting equipment, coordinating and/or performing repairs.

Basic Minimum Qualifications:

  • Bachelors or Masters Degree in Biotechnology, Biochemical Engineering, Analytical Chemistry, Chemical Engineering or other related fields.

Position is full-time, Monday-Friday 8am-5pm with overtime as needed. Candidates currently living within a commutable distance of Chesterfield, MO are encouraged to apply.

  • Excellent full time benefits including comprehensive medical coverage, dental, and vision options

  • Life and disability insurance

  • 401(k) with company match

  • Paid vacation and holidays

Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.



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VIEW JOBS 9/27/2020 12:00:00 AM 2020-12-26T00:00 Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies. In over just 30 years, Eurofins has grown from one laboratory in Nantes, France to over 47,000 staff across a network of more than 900 independent companies in over 50 countries and operating more than 800 laboratories. Eurofins offers a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products, as well as providing innovative clinical diagnostic testing services, as one of the leading global emerging players in specialised clinical diagnostics testing. In 2019, Eurofins generated total revenues of EUR € 4.56 billion, and has been among the best performing stocks in Europe over the past 20 years. Job Description: The successful candidate will lead analytical assay support for the Upstream Process Development (UPD) and Purification Process Development (PPD) groups, based in Chesterfield, MO. The Upstream Process Development (UPD) group is responsible for developing robust processes for cell lines producing the protein therapeutics. These are proteins that are chosen by research units as the candidate molecules for the treatment of various medical conditions spread across oncology, neuroscience, inflammation and many others. The processes developed by the UPD group are used in GMP manufacturing facilities to produce the molecules in large quantities for clinical and commercial needs. One of the vital components of upstream process development is controlling the metabolism of the cells in culture. CHO cells consume large amounts of nutrients including amino acids and other metabolites to produce molecules of interest as well other byproducts. Quantification of amino acids in the culture medium, protein concentration, as well as several other metabolites and byproducts are key to building robust processes and ensuring product quality. The successful candidate will drive the analytical support for the team by performing analytical testing on culture samples. The Purification Process Development (PPD) group is responsible for developing robust purification processes that recover the protein therapeutic from the (above) culture medium. Typical technologies include liquid/solids separations via centrifugation, depth and membrane filtration, ultrafiltration, and chromatography. As with upstream, significant in-process analyses and characterization are required in developing, scaling and optimizing the large scale GMP manufacturing processes. The successful candidate will drive the analytical support to the team by performing analytical testing on purification samples. Job Responsibilities and Requirements: The successful candidate will drive analytical support efforts for the UDP and PPD process development groups - receiving and managing samples, performing required analytical tests, processing the data and providing data summaries back to the responsible scientists. For UPD group support, the successful candidate will preferably have hands-on experience or at least a basic knowledge of various analytical, cell culture and molecular biology techniques including but not limited to amino acid analysis using UPLC, titer assay using HPLC, and metabolite analysis using BioHT. For PPD group support, the successful candidate will preferably have hands-on experience or at least a basic knowledge and aptitude for relevant analytical and wet chemistry techniques including but not limited to analytical chromatography via UPLC/HPLC (using size-exclusion, ion-exchange, reversed-phase, and/or affinity methodologies), spectrophotometry, host cell protein (HCP) analysis via ELISA and/or Gyros methodologies, Caliper/CGE, SDS-PAGE. General requirements include performing data analysis using Microsoft Excel, composing scientific documents for electronic lab notebooks, and maintenance of experimental data in relevant electronic databases. Strong organizational skills and a readiness to support a safe working environment are also required. A working knowledge of Empower control and data analysis software is strongly preferred, as well as a willingness to interact with external vendors and/or internal site operations to solve instrument and/or facility issues. Additional responsibilities may include routine maintenance on UPLC/HPLC, calibrations, troubleshooting equipment, coordinating and/or performing repairs. Basic Minimum Qualifications: * Bachelors or Masters Degree in Biotechnology, Biochemical Engineering, Analytical Chemistry, Chemical Engineering or other related fields. Position is full-time, Monday-Friday 8am-5pm with overtime as needed. Candidates currently living within a commutable distance of Chesterfield, MO are encouraged to apply. * Excellent full time benefits including comprehensive medical coverage, dental, and vision options * Life and disability insurance * 401(k) with company match * Paid vacation and holidays Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer. Eurofins Scient. Chesterfield MO

Bioprocess Analytical Chemist

Eurofins Scient.