Bristol Myers Squibb Princeton , NJ 08544
What is Innovative Medicines at Bristol-Myers Squibb?
Innovative Medicines at Bristol-Myers Squibb is a global development and commercial organization focused on Cardiovascular, Fibrosis and Immunoscience therapeutic areas.
We are committed to unleashing innovative approaches to help patients prevail against serious diseases.
From research to customer-facing roles, we foster a collaborative culture and invest in meaningful development opportunities for our people and focus on the activities that increase the speed of the development and delivery of our innovative treatments.
We are a unique organization where team members are encouraged to have broad roles and to contribute beyond a single discipline, all in an effort to accelerate medicines to patients.
We are fast, adaptable and agile. Through focus, nimble decision making, and cross-functional coordination, we are fueling the growth of our marketed medicines and accelerating the delivery of our most promising assets.
Learn more about who we are and what we do for patients
Learn about our unique understanding of the immune system and how it connects our therapeutic areas
Explore additional areas of exciting science at Bristol-Myers Squibb, including fact sheets on specific assets in our pipeline
See the people behind our discoveries
Most importantly, hear from our patients, who are at the absolute center of everything we do
In this position, you will work in a matrix environment to:
Develop and deliver Translational Medicine Strategies for novel therapeutic agents to assess pharmacodynamics, patient selection, and understand the mechanism of action in the context of the disease pathophysiology. The results of these strategies will enable decision-making by the Clinical and Development teams and inform the selection of appropriate indications and doses. Communicate the results to a diverse audience both internally and externally. In this role, you will develop actionable biomarker plans consistent with the translational medicine and clinical development strategies as a part of the clinical team. You will manage the implementation of biomarker plans in clinical trials and be responsible for analysis of the biomarker data and CSR. Manage collaborations and communications with external vendors and academic thought leaders.
Delivers high quality translational medicine strategies for target engagement, pharmacodynamics, mechanism of action, and patient selection.
Develop the biomarker plans for multiple trials in different indications.
Manage the implementation of translational/ biomarker plan by effectively engages with technical/scientific experts in TM and IMD. Effectively interfaces with the Translational Medicine group to obtain appropriate resources to deliver on biomarker goals.
Collaborate with clinical development team to define biomarker components of statistical analysis plans.
Develop and implement exploratory analysis plans for biomarker and clinical data.
Collaborate with external partners and CROs conducting studies to ensure operational success
Collaborate with Translational Bioinformatics to define key questions and analysis plans for "Omics" and integrated clinical/biomarker data.
Collaborate with pharmacodiagnostics group to develop patient selection/stratification markers into pharmacodiagnostic tools.
Engage with internal and external vendors to investigate molecular mechanisms of action through management and communication of non-clinical studies.
Communicate effectively across the organization with Translational Medicine, Clinical Development, Disovery and Medical Affairs teams.
MD or PhD,
Experienced scientist with 5+ years' experience, including drug development experience and basic or translational immunology research
Deep understanding of the role of translational research/medicine and clinical biomarkers in drug development
Comfortable working in a fast-paced environment where speed is paramount
Comfortable working in or leading matrix team
Willing to work as a topic expert, outside of a traditional functional environment, in a team unified around serving the assets
Ability to recognize, articulate, and accept calculated risks to make informed decisions
Demonstrated experience in the appropriate application of various scientific technologies into translational research strategies
Working knowledge of all functional areas of drug development, including, biology, toxicology, clinical development, diagnostic development, etc.
Demonstrated scientific acumen and mechanistic understanding of disease biology