Wave Life Sciences USA seeks a highly motivated postdoctoral research fellow to join its team in Cambridge, Massachusetts. This is an ideal position for an individual with an interest in developing RNA-based therapeutics and who thrives in a team-oriented, fast-paced, and cross disciplinary biotech environment. The main area of focus for the project will be in the forefront of basic research into RNA epigenetic modifiers and how to perturb them using chemically designed small oligonucleotide therapeutics. The candidate will be an integral member of a small team of scientists aiming to rapidly and pragmatically realize the potential of a novel oligonucleotide therapeutics platform.
Work with scientists in the biology team to advance an early stage RNA targeting technology
Plan and execute experiments to optimize oligonucleotide design for the purpose of perturbing RNA epigenetic modifications across multiple different tissue and cell models
Rationally apply Wave's proprietary PRISM platform to improve oligonucleotide efficacy and design
Execute in vivo and in-vitro assays to characterize changes in the RNA epigenetic landscape and biochemical properties of the cellular RNA epigenetic machinery.
Prepare clearly articulated experimental reports and data presentations
Attend and contribute to discussions in weekly internal team meetings
Publish findings in high-quality peer reviewed scientific journals and/or relevant conferences
Education / Experience
Recent or upcoming graduate with a PhD in biochemistry, cell biology, molecular biology or related field
Experience with mammalian cell culture including transfection, RNA isolation, qPCR, etc.
Experience in studying RNA epigenetics is desired but not required
Familiarity with next generation sequencing methods and oligonucleotide therapeutics (antisense, siRNA, exon-skipping, etc.) is a plus
Skills / Pre-requisites
Effective communication and interpersonal skills
Excellent organizational skills with an ability to embrace change and multi-task in an extremely fast paced environment
Ability to innovate and think creatively to support and advance platform & drug development processes
Strong presentation skills; adept at presentation of clear and accurate reports for internal and external projects
Collaborative and self-motivated team player
Wave Life Sciences