Biological Scientist III

Classification Title:

Biological Scientist III

Job Description:

Screening: Hands-on small molecule and genomic screening and review/interpret results. Duties include: high-content imaging, drug dispensing using pin tools, mammalian cell culturing, mechanistic follow up studies using various molecular biology techniques, live cell staining, 3D organoid culture.

Assay Development: assay designing, development and miniaturization for HTS, develop 3D organoid cell culture techniques.

High-content assays for characterizing the viability and morphology of 3D organoid cultures using cell painting. Duties would include working closely with collaborators to develop assays to get them "screening-ready".

Data compilation and analysis: Data analysis using, automated image analysis with CellProfiler, Columbus, ImageJ, PhenoLOGIC or similar. Develop machine-learning/deep-learning based classifiers for image analysis to predict bioactivity in morphological screens.

General laboratory responsibilities. Maintain laboratory protocols and develop protocols to improve existing techniques.

Help with the organization and maintenance of the CNPD3 screening and tissue culture laboratories and its equipment. Instruct undergraduate and graduate students in methods and procedures. Maintain laboratory safety programs and train personnel in biological laboratory safety techniques.

Expected Salary:

Commensurate with education and experience

Minimum Requirements:

Bachelor's degree in biology or a closely related field and seven years of relevant experience; or a Master's degree in biology or a closely related field and five years of relevant experience; Doctoral degree in biology or a closely related field and two years of relevant experience.

Preferred Qualifications: •Previous experience in high-content imaging, fluorescence microscopy and quantitative image analysis using advanced computational techniques

.•Experience in machine learning techniques for image analysis.

• Skilled in tissue culture and molecular biology techniques.

• Familiarity with drug/genomic library screening and instrumentation and an understanding of basic approaches in cell-based assays

.•Experience managing, training, and working with graduate students and postdoctoral fellows

• Knowledgeable in mechanistic follow-up studies for drug leads.

• Ability to multi-task and meticulous in recording, tracking and reporting of data collected for grants, publications and presentations. Special Instructions to Applicants:

For consideration, applicants must upload a CV, cover letter, and list of at least 3 professional references. Application must be submitted by 11:55 p.m. (ET) of the posting end date.

The University of Florida, College of Pharmacy, strives to stimulate a culture that promotes diversity and inclusion within an exceptional community of students, faculty and staff. We welcome applicants from diverse backgrounds and are committed to developing leaders who respect, support and have a positive impact on all individuals.