Bioinformatics Scientist II

Children's Hospital Of Philadelphia Philadelphia , PA 19107

Posted 7 days ago

"

CHOP EMPLOYEE? SEARCH FOR JOBS HERE.

Bioinformatics Scientist II

Philadelphia, PA, US, 19146

Job Type:

Req ID: 24915

Shift: Days

Employment Status: AF - Active

  • Regular

  • Full Time

Job Summary

The Center for Data-Driven Discovery in Biomedicine (D3b - d3b.center) is seeking talented bioinformatics scientist to build and scale solutions for accelerating discovery and advancements in child health. We're looking for creative problem solvers who can leverage software and system engineering to perform large-scale genomic analysis. You will be involved in research projects that contain large cross-disease cohorts which are being characterized with next-generation sequencing. This position is an entry level position for a PhD level professional and a 2nd stage position for those with moderate experience without a PhD. The focus of the position is service-level application of bioinformatics tools and methods to bench and clinical research problems in various biomedical domains. The position allows for a wide variety of activities described within the job responsibilities and encompasses positions within both research and clinical environments. Activities occur with a moderate degree of supervision with some latitude for independent judgment, development of bioinformatics workflows and processes, and presentation of results. The Bioinformatics Scientist II will begin to apply best practices in collaborative science as a bioinformatics domain expert. Academic output, while not a primary focus of this position, is also expected with a moderate degree of supervision. The Bioinformatics Scientist II is primarily focused on supporting scientific teams and projects as a bioinformatics domain expert.

Job Responsibilities

Pre-Analysis (20%): Contribute to the development of application portfolio by developing knowledge of internally developed systems, open-source programs, and commercial applications. Provide efficient data management support.

  • Use standard pipelines for data processing and manipulation in advance of performing analysis in a manner that best enables the analysis plan.

  • Contribute to the development of additional pipeline functionality and changes by providing knowledge of both collaboration-specific requirements and bioinformatics discipline advances.

  • Advocate for specific collaboration requirements for continual advancement of shared pipeline and code resources.

  • Provide collaboration-specific transparency for data processing and pre-analysis, including sample- and cohort-level status.

Coding (20%): Code and generally support code and applications on behalf of collaborative project and/or team.

  • Within the context of the collaboration or project, develop and apply best practices to code development.

  • Establish requirements with the project team.

  • Review existing applications and code sources (both commercial and open source) and selection of best strategy for development or adoption.

  • Advocate for chosen strategy to project team by showing value of approach

  • Develop best practices for project-based code development, QC, and execution consist with the expectations of specific collaborations.

  • Regularly seek peer-to-peer code reviews by participating in informal and formal critical code reviews.

Data Analysis (20%): Analyze data of high complexity by applying sound statistical and commonly accepted bioinformatics methods to -omics data primarily under the direction of the collaborative project team.

  • Develop robust analysis plans independently with regular peer-to-peer review in both informal and formal settings.

  • Incorporate more advanced applications and methods into analysis.

  • Develop at least one "specialty" analytical or biomedical area that serves the collaborative team.

Collaboration (20%): Establish role within collaborative project team as primary bioinformatics resource.

  • Contribute to and influence project-level management by serving as bioinformatics point.

  • Define and promote boundaries of support by assessing all stakeholders, including bioinformatics management, collaborator expectations, and funding levels and mechanisms.

  • Regularly discuss satisfaction and expectations with collaborators; continually advocate for clear understanding of role.

  • Develop new collaborations with high degree of supervision.

Academic Output (20%): Develop presentations, grant sections, and manuscript sections with subsequent review by peers and mentors.

  • Regularly contribute to bioinformatics-focused manuscripts and publications.

  • Regularly contribute to podium presentations and posters.

  • Contribute to bioinformatics sections of grant and award proposals.

Required Education and Experience

Required Education: Bachelor's Degree in biological or computational discipline.

Required Experience:

  • At least three (3) years of experience in applied bioinformatics, genomics, and computational work.

  • Experience with management and analysis of complex data types.

  • Experience with genomic/proteomic data analysis methods.

Preferred Education, Experience & Cert/Lic

Preferred Education: Master's or Doctorate Degree in biological or computational discipline

Preferred Experience:

  • Four (4) or more years of experience in applied bioinformatics, genomics, and computational work. This experience can be inclusive of a relevant PhD dissertation.

  • Experience with Python, Perl, or other languages.

  • Experience with pipeline or workflow development frameworks.

  • Experience or knowledge of technologies commonly used in biological labs, such as PCR, cloning, electrophoresis gels, and cell culture.

Additional Technical Requirements

  • Strong UNIX/LINUX expertise required.

  • Proficiency in R or similar commonly used bioinformatics language required.

  • Proficiency in various open source and commercial bioinformatics resources and software required.

  • Knowledge of the working mechanism of microarray, NGS, mass spectrometry, or other high-throughput technologies and awareness of their strengths and weaknesses, as well as applicability to a specific biological problem is preferred.

  • Familiarity with resources of genomic data sets and analysis tools, such as UCSC Genome Browser, Bioconductor, ENCODE, and NCBI databases is required.

  • Ability to correctly select and perform statistical tests for most types of genomic data, and to properly interpret their results in the scenario of a specific study is preferred.

  • Ability to interact with biologists and clinicians during a scientific discussion is required.

  • Accountability and attention to timelines.

  • Excellent organization and communication skills with an emphasis on strong presentation skills.

  • Ability to independently plan and execute analyses of moderate complexity required.

  • Ability to provide objective validation of results required.

  • Ability to work in a team environment.

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

VEVRAA Federal Contractor/Seeking priority referrals for protected veterans. Please contact our hiring official with any referrals or questions.

CHOP Careers Contact

Talent Acquisition
2716 South Street, 6th Floor

Philadelphia, PA 19146

Phone: 866-820-9288

Email:TalentAcquisition@email.chop.edu

CHOP EMPLOYEE? SEARCH FOR JOBS HERE.

Nearest Major Market: Philadelphia

Job Segment: Medical, Patient Care, Linux, Unix, Healthcare, Research, Technology


icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Bld Bnk Med Lab Scientist II Per Diem

University Of Pennsylvania Health System

Posted 1 week ago

VIEW JOBS 3/9/2019 12:00:00 AM 2019-06-07T00:00 The Penn Presbyterian Medical Center Laboratory is looking for a Blood Bank Medical Lab Scientist! Responsibilities of this position include but are not limited to the following: * Performing waived, moderate and/or high-complexity tests and procedures in clinical laboratory sections under the direction of the Supervisor * Performing appropriately requested clinical laboratory analyses on all types of laboratory specimens, produces and documents accurate laboratory results for diagnosis and treatment of disease * Adhering to Penn Medicine's policies and procedures and conform to all safety practices * Maintaining specified laboratory documents required by various accreditation agencies * Maintaining the confidentiality of health information on all patients * Performing testing of specimens and processing of blood products in accordance with Standard Operating Procedures * Performs antibody identification and utilizes reference reagents and special techniques appropriately * Accurately performing and documenting suspected transfusion reaction investigations * Documenting results accurately using computer and manual methods * Inspectingpatient samples for testing and ensuring compliance with Blood Bank labeling criteria * Selecting blood products for transfusion according to the Standard Operating Procedure to meet specific patient needs * Issuing blood and blood products in accordance with Standard Operating Procedures * Communicating with patient’s care team and the Blood Bank Resident/Medical Director/Attending in critical situations, when a delay is anticipated due to product availability or special requests * Modifying blood products according to Standard Operating Procedures * Maintaining appropriate blood and blood component inventory levels, orders products * Inspecting units for acceptability, performing confirmation testing when required, rotating units to ensure oldest are used first and discarding expired products * Performingequipment and reagent QC at required intervals, recognizing QC failures, and taking appropriate remedial action * Maintaining a clean, orderly and safe work area •Compling with Hospital and Laboratory safety requirements and completing mandatory safety training on or prior to due date * Identifing the need to deviate from Standard Operating Procedures and Policies, obtaining appropriate approval and documents events * Executing the use of all special transfusion protocols * Understanding and following the Quality System, including documenting and timely reporting of all failures to follow Standard Operating Procedures appropriately * Participating in the training of new employees and MLS students * Inspecting critical supplies and maintaining them according to Standard Operating Procedure and notifying the supervisor when supplies need to be replenished * Performing duties in accordance with Penn Medicine and entity values, polices, and procedures * Other duties as assigned to support the unit, department, entity, and health system organization University Of Pennsylvania Health System Philadelphia PA

Bioinformatics Scientist II

Children's Hospital Of Philadelphia