Bioinformatics Scientist / Engineer

At Profluent, data is our lifeline. Our generative models learn the blueprint of life by modeling large-scale evolutionary data. We are seeking a Bioinformatics Scientist / Engineer to perform genomic data mining to expand the known universe of biological sequences.

This is an excellent opportunity to shape the future of AI-driven protein design and to work cross-functionally with a diverse team of experts across machine learning, protein engineering, cell biology, and gene editing.

Responsibilities

• Perform large-scale metagenome assembly across the NCBI Sequence Read Archive

• Maintain and expand the world's largest database of protein sequences

• Deploy cloud-based pipelines to process large-scale genomic datasets

• Build cloud databases for scalable storage and fast retrieval of terabases of genomic data, including genomes, genes, proteins, and structures

• Clearly document code and communicate outcomes to colleagues

Qualifications

• BS, MS, or PhD in Bioinformatics, Genomics, Computer Science, or a related quantitative bioscience field

• 3+ years of industry or postdoc experience

• Experience working with Google Cloud Platform (GCP) or other cloud-based compute services (e.g. AWS)

• Experience building cloud pipelines, pipelining tools (snakemake, nextflow), and containerized applications (docker)

• Experience with highly parallelized cloud-based computing platforms (Batch or Kubernetes)

• Experience with scalable databases (BigTable, BigQuery, Snowflake) and proficient in database programming (SQL)

• Fluent in Python data analysis tools (numpy, pandas, Jupyter notebook, biopython)

• Experience with Linux environments and version control (git)

• Pays attention to detail, highly organized, and excels in a fast-paced work environment

Preferences (but not required)

• Experience with bioinformatics sequence analysis and alignment tools

• Experience working with next-generation sequencing data

• Familiarity with public repositories like UniProt, EBI, JGI, NCBI, and SRA

• Familiar with concepts in molecular biology, biochemistry, and structural biology

• Biological knowledge about prokaryotic gene and genome structure

• Publications in major scientific journals or conferences