Associate Scientist/Senior Associate Scientist, In Vivo Pharmacology

KSQ Therapeutics Cambridge , MA 02238

Posted 2 weeks ago

At KSQ Therapeutics, we seek to understand the role of every human gene in each disease, each tissue, and each cell that we study. This comprehensive approach has resulted in a massive, experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immuno-oncology product development. Utilizing this approach, we also identified a number of opportunities for the development of new medicines. As a result, we have aggressively invested in these distinct, highly validated pathways for new drug development with the expectation that the medicines we create may become the next breakthrough products for patients.

Founded in late 2015, KSQ is a preclinical-stage biotech that has rapidly advanced the field of CRISPR-enabled functional genomics, from in vitro cell autonomous screens to more complex genome-scale screens of immune cells in vivo. The company has expanded the scope of its technology to include multiple cell types and to unlock areas beyond oncology. KSQ is led by a team of accomplished industry experts in drug discovery and development.

Requirements

We seek a motivated and team-oriented individual who will be a key contributor to multiple programs within the KSQs autoimmunity and IO pipelines. The successful candidate will contribute hands-on technical expertise for all aspects of in vivo pharmacology including model development, efficacy studies and mechanism of action studies to help evaluate pipeline candidates and better understand their biology. This candidate will be a key contributor to several stages of drug development, including, target validation, exploratory biology efforts and IND enabling activities.

  • B.S. with 1+years of experience in an industry setting.
  • Experience in small animal handling with an understanding of animal behavior and applicable regulations around animal care/safety/handling
  • Demonstrated ability to perform compound or cell administration by a variety of routes (PO, IP, SC, IV) is desirable.
  • Experience with necropsy and sample collection including whole blood and tissues e.g. tumor and spleen
  • Perform a wide variety of in vivo techniques across multiple projects with delivery of high-quality data.
  • Expand on ex vivo capabilities to contribute to key mechanistic understanding of targets
  • Responsible for data entry and analysis from all studies in a timely manner while communicating experimental results to manager and a wider audience when required.
  • Work collaboratively within department and across departments to effectively achieve project goals and timelines.
  • Be high energy, adaptable and open-minded while working in a collaborative, innovative and fun environment.
  • Proven ability to perform ex vivo sample/tissue preparation. Experience in executing ex vivo assays to investigate therapeutic MOA by flow cytometry, is desirable.
  • Tissue/cell culture experience is preferable including cell passaging and harvesting
  • Experience with autoimmune and/or immune-oncology in vivo models is preferrable.
  • Knowledge of immunology and autoimmunity concepts is desirable.
  • Excellent verbal and written communication and interpersonal skills for participating across functional groups and externally.
  • Covid-19 vaccination is a condition of employment at KSQ, subject to reasonable accommodation where required by law. Employees must be fully vaccinated by date of hire to be considered.

The successful candidate will:

  • Perform a wide variety of in vivo techniques across multiple projects with delivery of high-quality data.
  • Expand on ex vivo capabilities to contribute to key mechanistic understanding of targets
  • Responsible for data entry and analysis from all studies in a timely manner while communicating experimental results to manager and a wider audience when required.
  • Work collaboratively within department and across departments to effectively achieve project goals and timelines.
  • Be high energy, adaptable and open-minded while working in a collaborative, innovative and fun environment.
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Associate Scientist/Senior Associate Scientist, In Vivo Pharmacology

KSQ Therapeutics