Associate Scientist, Therapeutic Discovery

Precision Biosciences Durham , NC 27701

Posted 2 months ago

This position is not eligible for relocation assistance.

Summary

The Associate Scientist is responsible for the design and execution of experiments to further characterize and understand the mechanism of action of ARCUS nucleases in mammalian cell systems. The Associate Scientist will also apply this knowledge to developing improved applications of ARCUS technology.

Essential Duties and Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.

The Associate Scientist will:

  • Coordinate with the Director of Therapeutic Discovery to design and execute experiments to characterize ARCUS nucleases.

  • Conduct experiments to understand mechanism of action of ARCUS nucleases within mammalian systems

  • Define pathways involved in potential toxicity of nuclease overexpression

  • Apply cell biology understanding to aid in the design and testing of improved nucleases

  • Contribute to the design and execution of cell culture based experiments

  • Design experimental approach to understand DNA repair pathways in the context of ARCUS nuclease

  • Utilize ARCUS Nucleases to generate proof-of-concept data demonstrating therapeutic approach or mode of action in model system

  • Define disease-specific cell signaling pathways and explore ARCUS-based modification of pathways for therapeutic application

  • Serve as Precisions Cell Biology Expert for internal and external purposes

  • Report results to Therapeutic Discovery team

  • File reports for internal use and for partners.

  • Generate graphs, slides, protocols and other documents for partners.

  • Present at lab meetings.

  • Participate in conference calls with partners/clients as needed.

  • Publish results as appropriate.

  • Share potential intellectual property developments with CSO and Patent Attorney/Agent

Qualifications

The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

Education/Experience

  • PhD or equivalent in Biological Science with related experience and/or training:

  • Plasmid and genomic DNA isolation

  • RNA isolation

  • Molecular Cloning techniques for Vector construction

  • PCR, qPCR

  • DNA Sequencing

  • Cell Culture

  • DNA, RNA Transfection and Viral Transduction for expression in Eukaryotic Cells Systems

  • Protein Characterization by Western, Flow Cytometry, and ELISA

  • Cell Based Assay development

  • Experience with genome editing is a plus

Language Ability

  • Ability to read, analyze, and interpret common scientific and technical journals, financial reports, and legal documents.

  • Ability to respond to common inquiries or complaints from customers, regulatory agencies, or members of the business community.

  • Ability to write speeches and articles for publication that conform to prescribed style and format.

Math Ability

  • Ability to work with mathematical concepts such as probability and statistical inference, and fundamentals of plane and solid geometry and trigonometry.

  • Ability to apply concepts such as fractions, percentages, ratios, and proportions to practical situations.

Reasoning Ability

  • Ability to define problems, collect data, establish facts, and draw valid conclusions.

  • Ability to interpret an extensive variety of technical instructions in mathematical or diagram form and deal with several abstract and concrete variables.

Computer Skills

  • To perform this job successfully, an individual should have knowledge of the Microsoft Office Suite, DNA sequence analysis software (SnapGene, Vector NTI or similar).

Work Environment

The work environment characteristics described here are representative of those an employee could potentially encounter while performing the essential functions of this job.

  • While performing the duties of this job, the employee is occasionally exposed to work near moving mechanical parts and fumes or airborne particles.

  • The noise level in the work environment is usually moderate.

Physical Demands

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

  • The employee must occasionally lift and/or move up to 50 pounds.

  • Specific vision abilities required by this job include close vision, distance vision and depth perception.

  • While performing the duties of this Job, the employee is regularly required to stand; walk; sit; use hands to finger, handle, or feel; reach with hands and arms and talk or hear.

Travel Requirements

  • This position requires little travel.

Precision BioSciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training. ?


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Associate Scientist Therapeutic Discovery

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VIEW JOBS 9/21/2018 12:00:00 AM 2018-12-20T00:00 This position is not eligible for relocation assistance. Summary The Associate Scientist is responsible for the design and execution of experiments to further characterize and understand the mechanism of action of ARCUS nucleases in mammalian cell systems. The Associate Scientist will also apply this knowledge to developing improved applications of ARCUS technology. Essential Duties and Responsibilities Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document. The Associate Scientist will: * Coordinate with the Director of Therapeutic Discovery to design and execute experiments to characterize ARCUS nucleases. * Conduct experiments to understand mechanism of action of ARCUS nucleases within mammalian systems * Define pathways involved in potential toxicity of nuclease overexpression * Apply cell biology understanding to aid in the design and testing of improved nucleases * Contribute to the design and execution of cell culture based experiments * Design experimental approach to understand DNA repair pathways in the context of ARCUS nuclease * Utilize ARCUS Nucleases to generate proof-of-concept data demonstrating therapeutic approach or mode of action in model system * Define disease-specific cell signaling pathways and explore ARCUS-based modification of pathways for therapeutic application * Serve as Precisions Cell Biology Expert for internal and external purposes * Report results to Therapeutic Discovery team * File reports for internal use and for partners. * Generate graphs, slides, protocols and other documents for partners. * Present at lab meetings. * Participate in conference calls with partners/clients as needed. * Publish results as appropriate. * Share potential intellectual property developments with CSO and Patent Attorney/Agent Qualifications The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully. Education/Experience * PhD or equivalent in Biological Science with related experience and/or training: * Plasmid and genomic DNA isolation * RNA isolation * Molecular Cloning techniques for Vector construction * PCR, qPCR * DNA Sequencing * Cell Culture * DNA, RNA Transfection and Viral Transduction for expression in Eukaryotic Cells Systems * Protein Characterization by Western, Flow Cytometry, and ELISA * Cell Based Assay development * Experience with genome editing is a plus Language Ability * Ability to read, analyze, and interpret common scientific and technical journals, financial reports, and legal documents. * Ability to respond to common inquiries or complaints from customers, regulatory agencies, or members of the business community. * Ability to write speeches and articles for publication that conform to prescribed style and format. Math Ability * Ability to work with mathematical concepts such as probability and statistical inference, and fundamentals of plane and solid geometry and trigonometry. * Ability to apply concepts such as fractions, percentages, ratios, and proportions to practical situations. Reasoning Ability * Ability to define problems, collect data, establish facts, and draw valid conclusions. * Ability to interpret an extensive variety of technical instructions in mathematical or diagram form and deal with several abstract and concrete variables. Computer Skills * To perform this job successfully, an individual should have knowledge of the Microsoft Office Suite, DNA sequence analysis software (SnapGene, Vector NTI or similar). Work Environment The work environment characteristics described here are representative of those an employee could potentially encounter while performing the essential functions of this job. * While performing the duties of this job, the employee is occasionally exposed to work near moving mechanical parts and fumes or airborne particles. * The noise level in the work environment is usually moderate. Physical Demands The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. * The employee must occasionally lift and/or move up to 50 pounds. * Specific vision abilities required by this job include close vision, distance vision and depth perception. * While performing the duties of this Job, the employee is regularly required to stand; walk; sit; use hands to finger, handle, or feel; reach with hands and arms and talk or hear. Travel Requirements * This position requires little travel. Precision BioSciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training. ? Precision Biosciences Durham NC

Associate Scientist, Therapeutic Discovery

Precision Biosciences