Associate Scientist T Cell Engineering

Intellia Therapeutics Cambridge , MA 02138

Posted 1 week ago

At Intellia, we are revolutionizing medicine by harnessing the power of genome editing to develop potential cures. We bring new hope for people living with conditions including cancer, genetic disorders, viral infections, inflammatory disorders and many more.

SUMMARY:

Would you like to work in a company that is energetic, exciting, and fun? If so, Intellia may be the place for you!

An exciting opportunity for an immunologist is available in our ex vivo group; where we leverage top-notch CRISPR and other gene editing technologies to fully unleash the power of cell-based therapy for Autoimmune and Immuno-Oncology indications. The ideal candidate is versed in T cell immunology with a strong interest in T cell engineering and knowledge of T cell biology and related assays.

GENERAL RESPONSIBILITIES:

Design, implement, and troubleshoot experiments, both independently and in collaboration with colleagues, to reach desired goals

Establish in vitro assays to support T cell projects

Work closely with the CMC team on scale-up efforts

Execute in vitro Receptor-Ligand assays to assess surface receptor expression and function

Perform in vivo PK/PD assays to guide cell design selection

Communicate research and development findings with internal teams in a clear and concise manner

Diligent and timely documentation of experiments in ELN and reports

REQUIRED SKILLS:

Hands-on experience with human T cell culture, T cell isolation techniques, activation and transduction of T cells, T cell expansion, multicolor flow cytometry for T cell phenotyping and functional readouts

Strong background in human T cell-based assays, including proliferation assays, cytotoxicity assays, ELISA, and multiplexed cytokine assays

PREFERRED SKILLS:

Experience with T cell engineering, such as CAR-T or transgenic TCR T cells

Experience with in vivo tumor models

QUALIFICATIONS:

BS or MS in immunology, cell biology or related field with 5-8 years wet lab experience, preferably with some industry experience

Excellent interpersonal skills and ability to work efficiently and productively in a highly dynamic, scientifically rigorous, and fast-paced environment

Ability to optimize complex protocols and assays to meet desired outcomes

Ability to quickly adapt and learn when faced with new challenges

Strong motivation to deliver solid scientific results and focus on delivering on goals and timelines

Strong organizational skills and the ability to handle multiple projects in parallel

Effective verbal and written communication skills

Strong problem-solving and analytical skills

What Intellia Stands For?

At Intellia, our mission is to develop potentially curative genome editing treatments that can positively transform the lives of people living with severe and life-threating diseases.

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

  • One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us trusting and counting on every single one of us.

  • Explore because we seek new ways to tackle disease. Explore with unbounded mindsfree from assumptions, open to ideas.

    Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

  • Disrupt by thinking courageouslyand creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughtswith that breed of skepticism that shows you have better solutions.

  • Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standardseven when nobody is watching.

    Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants.

We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.



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Associate Scientist T Cell Engineering

Intellia Therapeutics