Associate Scientist II, In Vivo Discovery

At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.

We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.

Together, we are leading the way towards a healthier and more equitable future.

Position Summary:

The Preclinical Discovery team at Editas is focused on developing novel gene editing strategies for in vivo gene editing programs and is looking to add a highly talented and motivated candidate to help develop delivery strategies for gene editing machinery into target cells in vivo. This individual will help the development of novel cellular targeting strategies and implement these technologies to treat therapeutic indications with significant unmet medical needs. In addition, they will provide molecular biology and cellular assay development support to Editas’ in vitro and in vivo pre-clinical studies. With a strong foundation in cellular and in vivo biology, this person will work within cross-functional teams including Advanced Technologies, Human Genetics and Genomics, Platform Technology, and Translational Science in development and commercialization of in vivo gene editing drug products.

Key responsibilities:

• Development and optimization of molecular assays for evaluating editing outcomes of CRISPR-based therapeutics in an in vivo context. 
• Work with primary cells and cell lines.
• Develop and perform in vitro cell-based assays supporting the pharmacology of CRISPR-based therapeutics.
• Support in vivo studies for evaluation of LNP targeting and biodistribution.
• Maintain an electronic lab notebook in a timely fashion.
• Analyze and present data within the organization.
• Collaborate with internal teams to develop assays for robust detection of LNP cargo, LNP dynamics, and LNP targeting.

Requirements

Required Qualifications:

• BS/MS in Biology or related discipline and 6+/4+ years of hands-on research experience in academic and/or pharmaceutical/biotech environment.
• Skilled in molecular assays including PCR and flow cytometry. Demonstrated knowledge in assay development and optimization.
• Cell culture experience and experience with cell-based assays.
• Animal handling experience is a must.

Preferred Qualifications:

• Hematopoietic stem cell culture experience is a plus.
• Self-motivated, result-driven with excellent attention to details and ability to independently execute protocols to drive assignments to completion.
• Team oriented and excel in a fast-paced and dynamic team environment.
• Excellent oral and written communication skills.
• Well-organized and excellent at multi-tasking.
• Ability to form hypotheses, think critically, extract conclusions from datasets to inform future studies.

Benefits

Benefits Summary:

Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

If you are a results-focused and collaborative professional with a passion for advancing transformative therapies, we invite you to apply. Join us at the forefront of genetic innovation and be a key contributor to Editas Medicine's mission of redefining healthcare through cutting-edge genetic technologies.

Fostering Belonging. Fueling Innovation. Transforming Lives.