Associate Scientist I (Immunology & Cell Biology)

Macrogenics Rockville , MD 20850

Posted 2 months ago

MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 300+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer as well as various autoimmune disorders and infectious diseases. Our products and platforms have attracted multiple partnerships with leading pharmaceutical companies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position

The Associate Scientist I is responsible for characterizing biologic drug candidates by performing in vitro cell-based bioassays/experiments in the fields of immunology, cell biology and oncology. This individual is also responsible for analyzing data, providing interpretations, recommendations and conclusions in a timely and accurate manner. This position works closely with other functional groups to provide technical support for processing and analyzing patient blood samples from early phase clinical immunotherapy trials.

Responsibilities and Job Duties

  • Designs and executes in vitro immune cell-based experiments within given key parameters/instructions while ensuring data quality and timely execution

  • Seeks to understand the broad objectives of the project as well as the individual role in achieving those objectives, and modifies experimental plan when required

  • Analyzes research data accurately and interprets research results to answer scientific questions

  • Writes assay protocols and experimental procedures incorporating scientific rationale and necessary technical information for assay development

  • Operates laboratory instruments including a flow cytometer, fluorescent plate reader and cell sorter. Responsible for ensuring the instruments are properly maintained and for notifying the appropriate service providers to provide regular maintenance and/or repair the equipment in a timely manner

  • Learns, understands and masters new experimental techniques required for research

  • Processes human blood samples to support clinical immunotherapy trials

Qualifications

Education & Experience

  • Bachelor's degree in Cell Biology, Immunology or Molecular Biology or related discipline and a minimum of 5 years of directly related experience; or Master's degree in immunology, cell biology or related discipline with 2 years of directly related experience

  • Recent experience with isolation of human PBMCs and purification of major lymphocyte populations from human peripheral blood, flow cytometer-based immunophenotyping, lymphocyte proliferation assays, ELISAs, and culture of human lymphocytes.

Knowledge, Skills and Abilities

  • Strong knowledge of various analytical methodologies including but not limited to: flow cytometry and ELISA

  • Excellent mammalian cell or cell line culture skills

  • Knowledge of human and rodent immune cell biofunctions

  • Excellent record keeping, organizational, written and verbal communication skills

  • Ability to set up assays and conduct technical troubleshooting analysis

  • Ability to analyze data and provide a critical interpretation of results

  • Works collaboratively with other members of the team and research groups

  • Ability to handle multiple priorities in a fast-paced environment

  • Strong interpersonal skills for interfacing with other functional groups

Supervisory Responsibilities

None

Preferred Qualifications

Prior work experience in biotechnology and/or pharmaceutical companies

Statement

MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email info@macrogenics.com or call (301) 354-3566 and/or 711 for TTD/TTY service.

Equal Opportunity Employer/Veterans/Disabled


icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Scientist Iii Tumor Immunology

Macrogenics

Posted 2 weeks ago

VIEW JOBS 7/31/2019 12:00:00 AM 2019-10-29T00:00 MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 300+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer as well as various autoimmune disorders and infectious diseases. Our products and platforms have attracted multiple partnerships with leading pharmaceutical companies around the globe. The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization. Summary of Position This individual will contribute to the biological characterization of the Company's antibody-based oncology product candidates including both pre-clinical and clinical stage programs. Responsibilities and Job Duties: * Biological characterization of antibody-based therapeutics including multi-specifics. Data will be used to support lead molecule selection, IND and regulatory filings, and guide therapeutic opportunity in clinical setting. * Implement and execute immune based assays to characterize mechanism of activation (MoA) and potential combinatorial activity both within and between antibody-based molecules and/or other therapeutic modalities. * Apply state of the art of molecular and cellular technologies (inc multi-parameter flow cytometry and NGS) to characterize immune mediated tumor mechanisms Leverage research expertise in fields of innate and adaptive immunity in the tumor microenvironment (eg T-cell biology, TCR signaling, Tregs, MDSCs, TAMs) to discover and dissect novel therapeutic intervention strategies. * Participate in multi-functional teams responsible for antibody-based molecules ranging in development stage from early research through clinical development. * Provide day-to-day management of direct reports, guiding experimental planning and trouble-shooting, data interpretation and assembly. * Coach, mentor and manage people for performance and scientific growth. * Draft manuscripts and nonclinical sections for regulatory submission. * Provide external visibility through participation in scientific meetings and symposia. Qualifications Education Ph.D. or equivalent advanced degree – Immunology, Cell Biology or Biological Science Experience * Minimum of five years research post PhD * Industrial experience in a biotech/pharmaceutical company or equivalent Knowledge, Skills and Abilities * Expertise in tumor immunology as evidenced by high impact publications * Thorough understanding of cell-based assay technologies and experience with animal models for evaluation of immunotherapies * Hands-on experience employing immune based assays including multiparameter flow cytometry. * Capability in profiling of tumor infiltrate and characterization of functional activity of Tumor Infiltrating Lymphocytes a plus. * Capability in leveraging/monitoring immune-cell stimulatory and/or inhibitory activities mediated by molecular entities * Proficient in scientific documentation supporting submissions to regulatory agencies * An excellent scientific/clinical background as demonstrated through publications in basic medical science journals * Strong decision-making, complex problem-solving and critical data analysis and interpretation * Innovative with the ability to multi-task * Excellent written and verbal communication skills Supervisory Responsibilities Research Associate Statement MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email info@macrogenics.com or call (301) 354-3566 and/or 711 for TTD/TTY service. Equal Opportunity Employer/Veterans/Disabled Macrogenics Rockville MD

Associate Scientist I (Immunology & Cell Biology)

Macrogenics