Janssen Research & Development, LLC, a member of Johnson & Johnson's Family of Companies, is recruiting for an Associate Scientist I, located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.
We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.
Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, cardiovascular and metabolism, and pulmonary hypertension. Please visit http://www.janssenrnd.com for more information.
The Lead Discovery and Mechanistic Pharmacology team is a critical part of the Discovery Sciences (DS) organization is committed to the delivery of high-quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Area (TA) discovery teams. This mission requires deep scientific expertise in a number of disciplines, including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as an Associate Scientist I in the Enzymology group. This position will report to a senior member of the Lead Discovery and Mechanistic Pharmacology team.
The Associate Scientist I will be a key member of the Enzymology group in Lead Discovery and Mechanistic Pharmacology and will provide enzymology/biochemistry support and expertise to a variety of TA programs from target nomination through declaration of a clinical candidate. This individual will characterize enzyme function, develop innovative biochemical and biophysical assays, collaborate closely with our automation team to execute high-throughput screens to discover novel inhibitors and perform mechanistic studies to learn how they work. Deliver inhibitor potency and mechanistic data to enable optimization of lead chemical series and drive project progression. Collaborate in a highly multidisciplinary, matrix environment and be responsible for the clear communication of biochemical data to a diverse array of stakeholders on project teams.
A minimum of a Bachelor's degree in Biochemistry, Enzymology, Chemistry, Biophysics, Pharmacology or a related scientific discipline is required.
A minimum of 1 year of relevant experience with a Bachelor's degree or a Master's degree is required.
Experience and/or training in one or more of the following areas is required: development of biochemical assays, high-throughput screening, mechanism-of-inhibition studies, enzyme characterization, protein biochemistry, steady-state kinetics.
Direct experience developing and executing high-throughput biochemical and/or biophysical assays preferred.
Direct experience with detailed mechanistic characterization of ligand interactions with their targets preferred.
Experience with automated liquid handling systems preferred.
Must have excellent written and oral communications skills.
Must have strong quantitative analytical skills.
The ability to collaborate with scientists in multiple disciplines is required.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
United States-Pennsylvania-Spring House-Welsh & McKean Roads
Janssen Research & Development, LLC (6084)
Johnson & Johnson