Associate Scientist I Enzymology

Johnson & Johnson Spring House , PA 19477

Posted 2 months ago

Janssen Research & Development, LLC, a member of Johnson & Johnson's Family of Companies, is recruiting for an Associate Scientist I, located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.

We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, cardiovascular and metabolism, and pulmonary hypertension. Please visit http://www.janssenrnd.com for more information.

The Lead Discovery and Mechanistic Pharmacology team is a critical part of the Discovery Sciences (DS) organization is committed to the delivery of high-quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Area (TA) discovery teams. This mission requires deep scientific expertise in a number of disciplines, including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as an Associate Scientist I in the Enzymology group. This position will report to a senior member of the Lead Discovery and Mechanistic Pharmacology team.

The Associate Scientist I will be a key member of the Enzymology group in Lead Discovery and Mechanistic Pharmacology and will provide enzymology/biochemistry support and expertise to a variety of TA programs from target nomination through declaration of a clinical candidate. This individual will characterize enzyme function, develop innovative biochemical and biophysical assays, collaborate closely with our automation team to execute high-throughput screens to discover novel inhibitors and perform mechanistic studies to learn how they work. Deliver inhibitor potency and mechanistic data to enable optimization of lead chemical series and drive project progression. Collaborate in a highly multidisciplinary, matrix environment and be responsible for the clear communication of biochemical data to a diverse array of stakeholders on project teams.

Qualifications

Qualifications:

  • A minimum of a Bachelor's degree in Biochemistry, Enzymology, Chemistry, Biophysics, Pharmacology or a related scientific discipline is required.

  • A minimum of 1 year of relevant experience with a Bachelor's degree or a Master's degree is required.

  • Experience and/or training in one or more of the following areas is required: development of biochemical assays, high-throughput screening, mechanism-of-inhibition studies, enzyme characterization, protein biochemistry, steady-state kinetics.

  • Direct experience developing and executing high-throughput biochemical and/or biophysical assays preferred.

  • Direct experience with detailed mechanistic characterization of ligand interactions with their targets preferred.

  • Experience with automated liquid handling systems preferred.

  • Must have excellent written and oral communications skills.

  • Must have strong quantitative analytical skills.

  • The ability to collaborate with scientists in multiple disciplines is required.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location

United States-Pennsylvania-Spring House-Welsh & McKean Roads

Organization

Janssen Research & Development, LLC (6084)

Job Function

R&D

Requisition ID

2105982178W

icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Sr Associate Scientist

Johnson & Johnson

Posted Yesterday

VIEW JOBS 1/23/2022 12:00:00 AM 2022-04-23T00:00 Janssen Research & Development, LLC, a Johnson & Johnson Company, is hiring a Senior Associate Scientist, Lentiviral Vector Late Stage Development, to be part of the Lentiviral Vector Process Development team within API Cell and Gene Therapy organization, located in Springhouse, PA. At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies. The primary responsibilities of this position are: * Participate in cross-functional project teams, responsible for development of efficient and robust production processes for large scale lentiviral vector manufacturing * Authoring of technical reports, regulatory filing sections and health authority responses * Collaborate with internal and external organizations to support late stage development, commercial manufacturing and CMC-Reg teams * Samples management, data review and data trending * Work in a team to design/execute experiments to support lentiviral vector process development, characterization and troubleshoot * Work in a team environment, as well as contribute individually, to meet project timeline and objectives * Based in Spring House, PA, this job may require up to 10% of domestic and international travel. Qualifications Qualifications * A MS in Biological Sciences, Virology or Biochemical Engineering or related with at least 2 years of relevant experience is preferred * OR * A BS in Biological Sciences, or Biochemical Engineering or related with at least 4 years of relevant experience is preferred * Experience supporting late stage development, Tech Transfer and cGMP manufacturing support is required. * Experience with technical writing and regulatory filings is preferred. * Understanding of statistical analysis and data trending using programs such as JMP is preferred * Gene therapy and viral vaccine downstream process development and virus purification is preferred * Familiarity with analytical methods typically used to characterize viral vectors is preferred. * Strong communication skills, and ability to present findings to management is required. * Experience with team-based collaborations is required. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Primary Location United States-Pennsylvania-Spring House-Welsh & McKean Roads Organization Janssen Research & Development, LLC (6084) Job Function R&D Requisition ID 2105983202W Johnson & Johnson Spring House PA

Associate Scientist I Enzymology

Johnson & Johnson