Associate Principal Scientist, General Medicine Therapeutic Areas Biomarker Lead

Job Description

Translational Molecular Biomarkers (TMB) is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our Company's Research laboratories. TMB biomarker leads connect with colleagues in discovery and clinical development to ensure an effective biomarker strategy is in place to address key clinical questions and enable decision-making. TMB laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms of drug action and patient response.

The Biomarker Leads group within the TMB organization is seeking a highly motivated candidate to join our team. The individual will play a critical role in the design, delivery, and execution of biomarker plans for our Company's early and late phase clinical trials in the General Medicine therapeutic areas. The candidate for this Associate Principal Scientist position should have strong expertise and experience in translational science, and laboratory medicine. In addition, the individual should have a desire to operate in a highly collaborative and matrixed environment to support our pipeline.

The individual will have the following responsibilities:

• Design and deliver program- and study- level biomarker plans for early and late phase clinical trials in the General Medicine therapeutic areas.

• Lead cross-functional biomarker sub teams, serve as functional area representative to development teams, and support governance interactions for pipeline projects and milestones.

• Liaise with subject matter experts to identify and effectively implement target engagement, pharmacodynamic, proof-of-mechanism, and precision medicine biomarkers for clinical phase programs.

• Facilitate adoption of innovative technologies and methodologies for biomarker identification and analysis.

• Participate in the formulation of testable hypotheses for biomarker analyses, and interpretation of results to ensure meaningful and accurate conclusions are drawn.

• Contribute to biomarker-related presentations, publications, and engagements, both internally and externally.

Position Qualifications:

Education Minimum Requirement:

• BS, MS, or Ph.D. in a life sciences discipline (Biochemistry, Immunology, Molecular Pathology, Cell Biology, or related field)

Required Experience and Skills:

• PhD and 5 years OR MS and 8+ years OR BS and 12+ years of experience in the biotech or pharmaceutical industry, specifically in translational or biomarker sciences.

• Excellent interpersonal, project management, verbal, and written communication skills.

• Strong analytical and problem-solving abilities, with attention to detail and the ability to interpret complex data.

Preferred qualifications:

• Biomarker experience in Immunology or Inflammatory Diseases is advantageous.

• Demonstrated contributions to scientific community through abstracts, publications, and participation in conferences.

• Experience utilizing computational methods (AI/ML, bioinformatics, data science, etc.) to manipulate data to develop biomarker strategies is a plus.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

Under New York State, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected salary range:

$122,800.00 - $193,300.00

Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. For Washington State Jobs, a summary of benefits is listed here.

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Hybrid

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

n/a