Associate Principal Scientist, Computational Scientist

Merck & Co., Inc. Boston , MA 02298

Posted Yesterday

Requisition ID: RES002107

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

We are seeking a highly motivated and enthusiastic computational scientist to join a team dedicated to advancing Merck's Oncology and Immuno-Oncology pipelines. The successful candidate will:

  • Analyze, visualize and summarize NGS and other molecular data from oncology clinical trials and proprietary and public large molecular databases.

  • Use oncology molecular data to identify biomarkers and molecularly defined groups of patients most likely to benefit from individual therapies, with a focus on translating biomarker-driven strategies into the clinic.

  • Effectively present data analyses to inform and interact with stakeholders representing a wide span of internal organizations, including Therapeutic Area Biology, Pharmacology, Statistics, Translational Medicine, Clinical Development, Commercial and Medical Affairs.

Qualifications

Required:

  • A Phd in Engineering, Applied Mathematics, Bioinformatics, Computational Biology or related field with a significant computational and statistical component.

  • A minimum of 5 years of post-PhD experience applying computational methods, in cancer biology, in a pharma, biotech or academic setting, by using scientific computation environments (Matlab and/or R highly preferred).

  • Hands-on analysis experience with large genetic, genomic, and clinical datasets , with proven record of impact on the drug development process.

  • Hands-on experience with key NGS bioinformatics tools (BWA, GATK etc) and with linux high performance environment (shell scripting, python).

  • Experience with a matrix environment and ability to effectively collaborate with colleagues from a wide range of disciplines.

Preferred:

  • Understanding of the major concepts of immuno-oncology biology and of the interaction between tumor and the immune system as represented in molecular data.

  • Experience with analysis of data originating from clinical trials.

  • Working knowledge of methods of statistical learning and application to biological problems.

  • Experience with modern data mining techniques including ANNs.

  • Record of publishing in high profile scientific journals.

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we're counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we're inventing for life.

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to staffingaadar@merck.com.

Search Firm Representatives Please Read Carefully:

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Visa sponsorship is not available for this position.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

EEOC GINA Supplement

Job: Research Science Generic

Other Locations:

Employee Status: Regular

Travel: Yes, 10 % of the Time

Number of Openings: 1

Shift (if applicable):

Hazardous Materials: No

Company Trade Name: Merck

Nearest Major Market: Boston


Find your dream job anywhere
with the LiveCareer app.
Download the
LiveCareer app and find
your dream job anywhere
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Associate Principal Scienti...

Merck & Co., Inc.

Posted Yesterday

VIEW JOBS 6/17/2018 12:00:00 AM 2018-09-15T00:00 Requisition ID: BIO004881 Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare. Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. We are seeking a highly motivated associate principal scientist to join our Discovery Oncology team at Merck, Boston. The successful candidate will be responsible for validating novel immunotherapy targets and contributing to both biologics and small molecule drug discovery programs. Responsibilities include the development and execution of experimental strategies to define the mechanism of action of, and mechanism of resistance to, immune-therapeutic agents. S/he will perform in vitro and ex-vivo experiments to determine the functional effect(s) of candidate target activation/inhibition by using a variety of assays to interrogate immune end-points. Candidate will be involved in leading external collaborations with academic and industry partners. Candidate is expected to be up to date on advanced technologies for immunotherapy, actively apply new concepts as appropriate to continuously improve functional area capabilities as well as to keep abreast of published scientific literature. Qualifications Education: * PhD in Immunology or Cancer Biology with relevant postdoctoral experience and a minimum of 3 years of industry experience. Required: * Candidate should have expertise in Immune Oncology and extensive experience with both T cell biology and myeloid biology (i.e. MDSCs). * Candidate should have a solid understanding of current Immuno-Oncology approaches and motivation to advance new therapeutic targets * Candidate is required to be a strong team player with excellent oral and written communication skills and with a demonstrated ability to work independently to design experiments, interpret data, troubleshoot, and suggest next steps. * Candidate should have the ability to multitask and perform in matrixed, multifunctional teams * Candidate is required to have excellent oral and written communication skills and with demonstrated ability to work independently to design and execute experiments, interpret data, troubleshoot and resolve technical challenges. * Candidate must have expertise in developing in vitro and in vivo assays to investigate immune function and possess knowledge of technologies commonly used to assess immune endpoints. * Candidate should have experience in the isolating, differentiating and manipulating primary human and mouse immune cells as well as experience in growth and maintenance of cell lines, proliferation and apoptosis assays, immunoassay techniques/platforms such as MLR, ELISA, Mesoscale Preferred: * Demonstrated project leadership in industrial or academic setting * Experience in bio/pharmaceutical drug discovery research and animal tumor modeling * Experience with multi-parameter FACS and data processing * Experience either working with or leading collaborations with external academic, biotechnology, and contract research organizations. Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we're counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we're inventing for life. If you need an accommodation for the application process please email us at staffingaadar@merck.com. Search Firm Representatives Please Read Carefully: Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means. For more information about personal rights under Equal Employment Opportunity, visit: EEOC Poster EEOC GINA Supplement Job: Biology-Discovery Other Locations: Employee Status: Regular Travel: Yes, 10 % of the Time Number of Openings: Shift (if applicable): Hazardous Materials: Company Trade Name: Merck Nearest Major Market: Boston Merck & Co., Inc. Boston MA

Associate Principal Scientist, Computational Scientist

Merck & Co., Inc.