Associate Director/Director, Medical Research, Pulmonary

Acceleron Pharma Cambridge , MA 02138

Posted 2 months ago

Who are we?

Acceleron is a clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of therapeutics to treat serious and rare diseases. The Company's leadership in the understanding of TGF-beta superfamily biology and protein engineering generates innovative compounds that engage the body's ability to regulate cellular growth and repair.

Acceleron focuses its research and development efforts in hematologic, neuromuscular, and pulmonary diseases. In hematology, the Company and its global collaboration partner, Celgene, are developing luspatercept for the treatment of chronic anemia in myelodysplastic syndromes, beta-thalassemia, and myelofibrosis. Acceleron is also advancing its neuromuscular program with ACE-083, a locally-acting Myostatin

  • agent in Phase 2 development in facioscapulohumeral muscular dystrophy and Charcot-Marie-Tooth disease and is conducting a Phase 2 pulmonary program with sotatercept in pulmonary arterial hypertension.

What will you be doing?

Reporting to the VP of Medical Research/Pulmonary Therapeutic Area Head, the Associate Director/Director of Medical Research will provide medical leadership and guidance for Acceleron's clinical development programs in the pulmonary therapeutic area. This position will support the overall program development strategy and program goals ensuring the highest scientific/medical standards are met, including the achievement of goals that are consistent with the overall corporate vision, mission and objectives.

  • Initiating, communicating, and executing well-conceived clinical development plans in support of the discovery, development and commercial mission of Acceleron

  • Responsible for the strategic and operational medical input to the design, planning, initiation, completion, analysis and reporting of clinical trials in the pulmonary therapeutic area

  • Providing clinical input on all IND/NDA/BLA preparation activities including data collection, database lock, analysis and write-up of biomarker and pharmacodynamic endpoints

  • Developing and implementing ongoing projects with agreed upon strategic goals, product profiles, product development plans, and project plans to meet milestones and timelines en route to full development

  • Communicating Acceleron's clinical development goals and accomplishments to the external community, investigators, key opinion leaders and corporate partners

  • Participating in, and provide clinical support to business development activities on an as-needed basis

What are we looking for?

  • M.D. or M.D./Ph.D. degree required

  • Subspecialty training and board eligibility/certification in pulmonary or related discipline with or without critical care medicine preferred

  • Prior experience (2-5 years) working in the biopharmaceutical industry and/or academic setting within pulmonary therapeutic area indications preferred

  • Strong strategic planning and product evaluation

  • Familiarity with global regulatory and cGCP standards

  • Superb verbal and written communication and presentation skills

  • Excellent interpersonal, motivational and collaboration skills

  • Entrepreneurial spirit; comfortable with rapid change, resource constraints, and the need to be flexible about roles

How will you grow with us?

This opportunity will allow you to help drive the pulmonary therapeutic area at Acceleron and collaborate with knowledgeable and passionate team members. This position will enjoy and benefit from an ability to influence at an early stage the development of our pulmonary therapeutic area, including developing new areas of focus beyond the current focus on pulmonary arterial hypertension. Further, you will gain exposure to development programs outside of the pulmonary TA, including exposure within our hematologic and neuromuscular TA programs here at Acceleron. It is an exciting time to work at Acceleron, with our company growth and advancing drug pipeline. You will tackle exciting challenges in a fast-paced environment working with other professionals dedicated to applying our technology to improve the lives of patients with pulmonary disease while helping us to develop new critical initiatives within the pulmonary therapeutic area. Grow in your career and join our team!

  • In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and complete the required employment eligibility verification document form upon hire.
icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Physician Scientist Translational Research Leader Neurogastroenterology And Gastrointestinal Motility Associate Medical / Medical Director Translational Research

Takeda Pharmaceutical Company Ltd

Posted 2 weeks ago

VIEW JOBS 10/5/2019 12:00:00 AM 2020-01-03T00:00 By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that I agree with Takeda's Privacy Notice, Privacy Policy and Terms of Use. Job Description Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Physician Scientist in our Gastroenterology Drug Discovery Unit in our Cambridge office. At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Futureto people around the world. Here, you will be a vital contributor to our inspiring, bold mission. POSITION OBJECTIVES: The Physician Scientist; Translational Research Leader Neurogastroenterology and Gastrointestinal Motility focused on upper and lower gastrointestinal motility diseases is a global leader responsible to provide medical perspective to early research and target selection, define and implement translational medicine (TM) strategies/plans and to secure execution. * TM strategy/plan should describe the approach to and activities required to define patient population / segmentation and establish target engagement, proof of pharmacology and early evidence for clinical efficacy in phase 1/2a studies. * Define strategies and plans for revers translation of human tissue and clinical study data to support new target generation, patient segmentation and define implications for ongoing projects. * The successful candidate will play a critical role in progression of projects from early research to clinical Proof of Concept (PoC) in patients. POSITION ACCOUNTABILITIES: Key accountabilities: * As a leader within the GI DDU, working within a highly matrixed & virtual environment, provide medical perspective, TM strategies and plans required for Neurogastroenterology and Gastrointestinal Motility area * Responsible for establishing TM Strategies and Plans for project at project start and through PoC including revers translation for projects in the area together with research, biomarker and clinical groups. * The TM strategy define the approach to patient segmentation and to establish target engagement, proof of pharmacology and early evidence for clinical efficacy in phase 1/2a studies. * The TM plan describes the integrated activities required e.g. biomarker plan and phase 0 studies to establish and validate the measurements to be used for patient population / segmentation, target engagement, proof of pharmacology, and early clinical efficacy in phase 1b/2a * Provide strategies and plans for revers translation of human and clinical study data to support target validation and selection, establish implications to ongoing research projects and define new hypothesis for patient selection together with research and clinical. * Identifies and ensures the success of key external collaborations required to support TM plans or reverse translational activities. * Define and lead phase 0 clinical studies part of TM plans * Responsible to secure timely execution of TM plans with high quality driving decision making together with internal and external collaborators via successful multidisciplinary team working. Additional accountabilities: * Builds relationships & collaborates with scientific leaders, KOLs, academic partners, CROs and biotech and is an international subject matter expert. * Contributes key input to other GI DDU areas. * Is a member of the GI DDU matrix team and contributes to strategic decisions to advance research projects from early stages to developmental in a way that maximizes the likelihood of long term success. * Participate in evaluation of preclinical and clinical in licensing candidates from institutions and companies and provides expert input to GI business development team * Represents Takeda and is responsible for creating a presence in scientific community through scientific meetings, advisory boards, online research communities, etc. * Keeps up with the up-to-date scientific advancement (e.g. competitive situation, new technology, new research portfolio, and new partnership) and is well informed about current regulatory (FDA, EMA, etc.) requirements and trends. EDUCATION, EXPERIENCE, BEHAVIOURAL COMPETENCIES AND SKILLS: * M.D. with preferably a Ph.D or research experience and with significant industry and leadership experience. * Minimum of 10+ years of directly related experience within industry and academia with a proven leadership in translational research in Neurogastroenterology and Gastrointestinal Motility * Internationally recognized leader in area of expertise * Strong leadership and strategic skills and acumen. * Excellent written and verbal communication skills in English. * Capable of leading a multifunctional matrixed team comprised of scientists and physicians from within Takeda as well as external collaborators. * Has a proven track record in successfully executing translational work with proven bridge between experimental systems and human studies. TRAVEL REQUIREMENTS: * Requires approximately 20% or more travel, including international. TRAVEL REQUIREMENTS: * 25% National and International travel. WHAT TAKEDA CAN OFFER YOU: * 401(k) with company match and Annual Retirement Contribution Plan * Tuition reimbursement Company match of charitable contributions * Health & Wellness programs including onsite flu shots and health screenings * Generous time off for vacation and the option to purchase additional vacation days * Community Outreach Programs Empowering Our People to Shine Discover more at takedajobs.com No Phone Calls or Recruiters Please. Locations Cambridge, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time Takeda Pharmaceutical Company Ltd Cambridge MA

Associate Director/Director, Medical Research, Pulmonary

Acceleron Pharma