Associate Director, Mechanistic Biology & Profiling

Astrazeneca Waltham , MA 02154

Posted 3 months ago

At AstraZeneca, we're not afraid to do things differently. We're building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening up new ways to work, pioneering cutting edge methods and bringing unexpected teams together. As the US Associate Director of the Mechanistic Biology & Profiling Group in Waltham, US, you will pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe.

Discovery Sciences is a multi-faceted department which drives early drug discovery across AstraZeneca's global Research & Development portfolio. Mechanistic Biology & Profiling (part of Discovery Sciences), is a global, multidisciplinary department responsible for mechanism-of-action studies and compound profiling for efficacy and pre-clinical safety in support of the Oncology, Cardiovascular and Renal Disease, Respiratory, Inflammation & Autoimmunity, and Neuroscience portfolios.

If you're inspired by the possibilities of science to make a difference and ready to discover what you can do join us.

Main Duties and Responsibilities

Reporting directly to the Global Head of the Mechanistic Biology & Profiling Department you will set the vision and lead a team in generating pre-clinical pharmacology data to predict and understand compound (and novel drug modalities) efficacy.

As the Associate Director, US, you will lead and drive a high-performing team to provide early, impactful mechanistic insight to projects across the global disease areas, through a combination of in vitro enzymology, pharmacology, and quantitative cell biology. You will be a recognised and passionate leader, able to represent the department across a broad range of therapeutic projects and global initiatives within Discovery Sciences and the disease areas, and also externally. You will drive scientific and technical innovation, including through external collaboration and partnership. You will also be a key member of the Global Mechanistic Biology & Profiling Leadership Team, participating in setting and maintaining the strategic direction, scientific quality and efficiency of the department.

Essential Requirements


  • Minimum of a Masters, PhD preferred


  • PhD and 11+ years of related experience or a Masters and 15+ years of related experience

  • Proven track record of recruiting and developing a world-class group, and optimising team performance in a highly matrixed discovery project environment

  • Formal training and proven expertise in a quantitative biology-based discipline (enzymology, pharmacology)

  • Extensive experience in pre-clinical drug discovery, with deep knowledge of the use of mechanistic enzymology to aid translation from model systems through to clinical dose prediction

  • Proven track record of career progression, and significant external reputation in pharmacology and/or enzymology, gained through professional recognition, external presentation and publication in high-impact journals

  • Extensive experience of establishing and leading external collaborations and technology change projects to advance organisational capability

  • Track record of delivering results across a diverse project portfolio by driving strategic, scientific, financial and people performance

Desirable Requirements

  • Strong and energetic leader - able to articulate a vision for disease- agnostic Discovery missions, set direction and inspire commitment for preclinical Discovery.

  • Ability to manage internal expertise, capacity and resources to drive governance and decision-making regarding scientific portfolio support and technology development.

  • Is future orientated and strategic in thinking style.

  • Robust decision making informed by business and financial acumen and an understanding of competitor strategy.

  • Generates exceptional results by influencing, driving performance and collaborating across project and country boundaries.

Next Steps Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

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Associate Director, Mechanistic Biology & Profiling