Associate Director, Cell Line Development (24112-R-675-Cldc)

ArsenalBio, a privately held, clinical-stage programmable cell therapy company engineering advanced CAR T therapies for solid tumors, is seeking a talented Associate Director, Cell Line Development to work onsite based in our South San Francisco office.

ArsenalBio's mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer. With our programmable and computationally driven approach, our team is engineering living medicines to attack cancer's inherent multi-faceted nature and overcome the challenges of addressing solid tumors with cell therapy.

Driven by a collective of diverse experts across immunology, synthetic biology, molecular biology, automation and computational biology, we are united in purpose to deliver radical breakthroughs for people with cancer, and prioritize the team's outcomes over individual goals to achieve our company mission - together.

We are seeking a highly motivated individual to lead cell line development at ArsenalBio. Reporting to the Vice President of Preclinical Pharmacology, this role requires substantial expertise in cell line engineering and development. Deep knowledge and extensive experiences in oncology target biology and drug discovery is also highly desirable. The successful individual will not only oversee and lead the cell line development group but work closely with project teams throughout Discovery and Preclinical Development to design and generate engineered cell lines in support of preclinical programs.

What You Will Do:

• Lead a group of scientists that provides centralized support for cell line generation

• Lead the development, application and optimization of new technologies for modifying the genomes of mammalian cells

• Employ strategies for the genetic modification of cell lines

• Lead activities in generating and maintaining master and working cell bank inventories across a portfolio of engineered cell lines

• Lead analysis and QC processes on cell lines at the DNA and protein level

• Provide expert support for cell line engineering experiment design and assay development to the broader scientific team.

• Coordinate tasks across multiple projects, demonstrating prioritization and planning.

• Interpret and effectively execute experiments in line with project timelines and goals

• Maintain familiarity with current literature related to the scope of ArsenalBio's research focus

• Mentor scientists within the group in areas of technical expertise

What You Will Bring:

• PhD in Cell or Molecular Biology, Biological Sciences or a related field, with 5+ years of relevant research experience in industry or academia

• Expertise with CRISPR gene editing and lentiviral transduction workflows, cell engineering and cell culture

• Experience developing/optimizing gene editing protocols

• Experience analyzing mammalian cells by flow cytometry for target surface expression

• Experience with Fluorescence-activated cell sorting (FACS)

• Entrepreneurial behaviors demonstrated by agility, accountability, transparency, resourcefulness, and ability to get things done

• Ability to quickly learn new skills and knowledge on the job, demonstrate productivity, and deliver high-quality results

• Flexible mindset with ability to think outside the box, creative approach to problem solving, and comfort in working with ambiguous data in an open-ended, exploratory process

• Demonstrated ability to perform as a team player, with strong organizational skills, record keeping and interpersonal communication skills (verbal and written)

What We Will Offer You:

An opportunity to work with the best talent in the field of cell therapy, and be part of ONE TEAM to advance therapies to patients who need it most.

ArsenalBio has a generous and comprehensive benefits package that includes but is not limited to medical, dental, and vision as well as mental health resources, virtual and telehealth options, coaching, infertility treatment, parental leave and health savings accounts. We also offer flexible work schedules and flexible time off, which includes two extra "Arsenal Days of Rest" every quarter for employees to recharge.

We have a robust mentorship program, and comprehensive development tools to help employees take control of their career paths and grow into their best selves. ArsenalBio believes in investing in the well-being of our employees - both at work and at home, as they are our greatest asset. They bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.

We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

The estimated base salary offer for the preferred primary location of the San Francisco Bay area ranges from $169,000- $207,000. Salary ranges for other locations may vary from this range. Base pay offered may vary depending on job related knowledge, experience, education, and location. In addition to these factors, we believe in the importance of pay equity and consider internal equity of our current employees as part of any final offer.

To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.

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