Associate Director, Cell Engineering

Company Overview:

Myeloid Therapeutics is a clinical stage immunology company, engineering cutting-edge RNA technology to program immune cells to combat cancer and other deadly diseases. Myeloid is headquartered in Cambridge, MA. For additional information, please visit https://www.myeloidtx.com/ and follow us on LinkedIn and X/Twitter.

Position Summary:

Myeloid Therapeutics is seeking an innovation-driven Associate Director to join our RetroT Gene Editing team and contribute to the engineering and development of novel gene editing systems.

MyeloidTx has developed CRISPR-Enabled Autonomous Transposable Element (CREATE), a genome editing system that combines the programmability and precision of CRISPR/Cas9 with the RNA-mediated gene insertion capabilities of the human LINE1 (L1) element. CREATE represents a significant advancement in gene editing technology, establishing a new paradigm of RNA-based gene therapy.

We are seeking an Associate Director to enhance the CREATE technology, focusing on elevating editing efficiencies and broadening its application to disease-relevant primary cell types. This role offers the opportunity to lead a dedicated team within MyeloidTx, contributing to both internal research initiatives and vital external collaborations. The successful candidate will leverage their deep expertise in culture of primary hepatocytes and/or iPSC derived hepatocytes/neurons to contribute to optimization of delivery and gene editing efficiency. This is an opportunity for creative, outside-of-the box thinking and rapid learning and growth towards the development of a revolutionary gene editing technology.

Responsibilities:

• Lead a dedicated team of scientists and research associates in optimizing CREATE system design, delivery, and editing efficiencies across various cell types

• Design, produce, and refine RNA-based gene editing constructs by leveraging deep expertise in programmable DNA nucleases (Cas9, Cas12, etc.) and transposable elements

• Develop and implement NGS-based assays to comprehensively evaluate editing outcomes, including efficiency, fidelity, and off-target effects

• Spearhead a robust research plan built on well-controlled scientific experiments, documenting all planning and progress in an electronic lab notebook

• Effectively communicate findings and conclusions to the broader scientific team, external collaborators, and at scientific conferences

Qualifications and Education:

• Ph.D. in Genetics, Biochemistry, Molecular Biology or related disciplines with 3-5 years of industry experience.

• Extensive knowledge and a strong track record in the design, characterization, and/or preclinical development of novel CRISPR and related genome-editing systems and/or mobile genetic elements.

• In-depth expertise in qPCR, RT-qPCR and NGS sequencing for characterization of gene editing outcome are required.

• Demonstrated ability to innovate and think outside-the-box, pushing the boundaries of gene editing technology.

• Exceptional communication skills, with the ability to articulate complex scientific concepts in a clear and coherent manner.

• Adept at managing multiple projects in a dynamic, fast-paced environment, prioritizing effectively to drive progress.

• Track record of scientific innovation and thinking outside-of-the-box