Allergan plc (NYSE: AGN) is a bold, global pharmaceutical company and a leader in a new industry model - Growth Pharma. Allergan is focused on developing, manufacturing and commercializing branded pharmaceutical, device, biologic, surgical and regenerative medicine products for patients around the world.
Allergan markets a portfolio of leading brands and best-in-class products for the central nervous system, eye care, medical aesthetics and dermatology, gastroenterology, women's health, urology and anti-infective therapeutic categories. With commercial operations in approximately 100 countries, Allergan is committed to working with physicians, healthcare providers and patients to deliver innovative and meaningful treatments that help people around the world live longer, healthier lives every day.
Allergan is a company that will inspire you to aim high with your ambition. Where you can build bridges all over the world. Where you can power ideas that drive change. And where you will act fast and drive results for customers and patients. Power your future & join our bold team.
The Associate Director, Biological Research will be an instrumental team member of the Research & External Scientific Innovation Department, based in Irvine, CA. The primary role of this position is to independently plan, design, and execute experiments to advance the development of natural and recombinant biopharmaceutical agents (e.g., lead molecule selection, formulation selection, characterizing mechanism of action, and/or evaluating alternate delivery modalities). The ideal candidate will possess strong experience in conceptualizing and driving complex research stage projects independently as well as in a team environment. This hands-on position will require characterization of protein-based therapeutics using a variety of methodologies. The candidate must have in-depth knowledge of cell-based assays as well as ex vivo and in vivo pharmacology models to assess the impact of drug candidates on the peripheral nervous system. Experience with recombinant DNA technologies and protein engineering concepts is highly valued.
Furthermore, the position requires the individual to work with and in areas requiring select agents and Toxins access (i.e. Biosafety level 2 and biosafety level 3 laboratories). Access to and use of select agents is regulated by federal policies. Therefore, the candidate must conduct all work activities in compliance with Allergan internal and applicable regulatory requirements. Allergan internal requirements include compliance with ethics, environmental health and safety, financial, human resources, and general business policies, requirements and objectives.
Main Areas of Responsibilities
Independently design, plan, execute and interpret complex in vitro and in vivo pharmacological studies focused on peripheral nervous system function, with the goal of lead molecule and/or formulation selection, characterization of MOA, identification of new indications and/or alternate delivery.
Analyze and present results to multidisciplinary teams, prepare technical reports and drive strategy and goal setting.
Identify risks within function and develop contingency plans to mitigate risk.
Work on cross-functional teams to advance programs from research to development.
Identify and manage external academic, governmental and industrial relationships.
Manage key documentation and inventories in compliance with Federal Regulations
Evaluation of internal research and development programs and open science opportunities
Other Attributes to include:
Exhibit strong leadership skills, flexibility and a commitment to scientific excellence.
Highly motivated, hands-on experimentalist who thrives in a collaborative, multidisciplinary environment.
Possess strong interpersonal skills with a demonstrated ability for creative thinking.
Perform experiments with minimal supervision, demonstrate leadership skills and interact in a team environment.
Able to have a direct impact on department or project performance.
Ability to work within a structured environment following specific guidelines.
The below skills are attributes that may not be mandatory, but are definitely desired in the ideal candidate.
Extensive experience in characterizing natural and recombinant biopharmaceutical agents including developing, performing and troubleshooting a wide variety of in vitro, ex vivo and in vivo pharmacological assays.
Demonstrated ability to work independently as well as in a team environment, multitask and ensure flexibility in a dynamic environment required.
Excellent oral and written communication skills required as is experience with documentation of experimental plans, analyzing data and generating high quality technical reports.
Knowledge of policies and procedures of working with regulated biological agents. Strong team leadership and motivational skills.
Experience with proactive and critical evaluation of internal and external research and development programs and open science opportunities.
Extensive experience with animal handling, dosing of small or large molecules through a variety of different routes, small animal surgeries and post-mortem tissue harvest.
Experience with histological techniques, including immunohistochemistry and standard staining, as well as microscopy techniques.
Experience with electrophysiology and ex vivo models of neuronal activity is a plus.
Experience with pharmaceutical development processes (including, but not limited to lead characterization, target engagement, pharmacokinetics, pharmacodynamics, immunogenicity assessments and basic toxicology) is a plus.
An understanding of protein engineering/design for desired biopharmaceutical characteristics is required and some experience with protein engineering is preferred.