Title Assistant Research Scientist
Why are we more susceptible to gastrointestinal cancers as we age?
Are there ways to screen for cancer susceptibility BEFORE it develops?
What is the role of the micro-organisms that live in your gut?
To address these questions, the laboratory of Dr. Juanita Merchant investigates how chronic inflammation in the hepatobiliary and luminal GI tracts leads to gastric and colon cancer. Mini-versions of these tissues can be generated from patient biopsies, and become a renewable source to study their response to various triggers, chemotherapy, inflammation, radiation. The laboratory uses a combination of technologies from molecular and cellular biology to whole genome analysis (NextGen Sequencing) of patient DNA to identify gene mutations and signaling pathways that might provide novel targets for therapy and the development of biomarkers to predict cancer susceptibility.
Microbial (16S) gene profiling is used to identify bacterial species and their byproducts, e.g., butyrate that can protect against inflammation and cancer. The position is a collaboration with translational research ongoing in the laboratory of Dr. Rachna Shroff who treats patients with hepatobiliary cancer and Dr. Yana Zavros, Associate Chair for Research in Cellular and Molecular Medicine who is the Director of the UA Organoid Core.
Outstanding UA benefits include health, dental, and vision insurance plans; life insurance and disability programs; paid vacation, sick leave, and holidays; UA/ASU/NAU tuition reduction for the employee and qualified family members; state and optional retirement plans; access to UA recreation and cultural activities; and more!
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The University of Arizona is in the process of creating a new classification and compensation architecture. This University Career Architecture Project (UCAP) will revolutionize the way we think about professions and manage compensation at the UA. It is a two year initiative that will replace the current classified staff and appointed professional categories of employment with market-based job functions and families. As an applicant, UCAP will create clearer career paths and opportunities and will help you make more informed pay decisions. To learn more about this project, please visit ucap.arizona.edu.
Duties & Responsibilities
Write IACUC protocols and perform animal experiments, including animal handling, maintenance of the transgenic colony, i.p. and s.c. injection, survival and non-survival surgeries, perform tissue harvesting and embedding.
Perform cell culture experiments.
Generate and passage organoid cultures from human and mouse tissue.
Perform standard laboratory procedures, including western blotting, immunoprecipitation, immunofluorescence and immunohistochemistry, ELISA, RT-quantitative PCR.
Perform basic mathematical and statistical analyses.
Prepare manuscripts and grants.
Knowledge, Skills, & Abilities
Good publication record.
Ability to plan, conduct experiments, analyze research data and prepare it for publications and grant submissions.
Ability to maintain good records.
Strong self-motivation, exceptional organization skills and high level of responsibility.
Ability to effectively prioritize the objectives.
Ability to work in a multidisciplinary collaborative environment.
Ability to supervise graduate and undergraduate students.
Complete fluency in written and oral English.
PhD in Physiology, Biology or a directly related field.
At least two years of experience in gastrointestinal research, rodent handling, live animal surgery and collection of gastrointestinal tissue collection.
The ideal candidate should also have hands on experience in molecular biology, western blot, ELISA and cell and organoid culture experience including genetic manipulations.
Understanding the redox biology and/or inflammatory/immune or proliferative pathways and experience in quantification/activity assays for these pathways are highly desirable.
Experience in qRT-PCR, isolation of gastrointestinal cells, live and fixed cell imaging; immunohistochemistry.
FLSA Exempt Full Time/Part Time Full Time Number of Hours Worked per Week 40 Job Category Research Benefits Eligible Yes
Posting Detail Information
Posting Number A24139 Number of Vacancies One Desired Start Date Position End Date (if temporary) Limited to Current UA Employees No Contact Information for Candidates
Open Date 10/07/2019 Close Date Open Until Filled Yes Review Begins On 10/17/2019 Special Instructions to Applicant Diversity Statement
At the University of Arizona, we value our inclusive climate because we know that diversity in experiences and perspectives is vital to advancing innovation, critical thinking, solving complex problems, and creating an inclusive academic community. As an Hispanic-serving institution, we translate these values into action by seeking individuals who have experience and expertise working with diverse students, colleagues, and constituencies. Because we seek a workforce with a wide range of perspectives and experiences, we provide equal employment opportunities to applicants and employees without regard to race, color, religion, sex, national origin, age, disability, veteran status, sexual orientation, gender identity, or genetic information. As an Employer of National Service, we also welcome alumni of AmeriCorps, Peace Corps, and other national service programs and others who will help us advance our Inclusive Excellence initiative aimed at creating a university that values student, staff and faculty engagement in addressing issues of diversity and inclusiveness.
Quick Link for Internal Postings http://uacareers.com/postings/41983
Required fields are indicated with an asterisk (*).
Where did you first learn about this position?
Arizona Daily Star
Chronicle of Higher Education
Department of Economic Security (DES)
Diverse Issues in Higher Education
Hispanic Outlook in Higher Education
Local Job Banks
Pima County One-Stop
Referred by UA Employee
Invited by Dept to Apply
Do you have at least two year of experience in gastrointestinal research, rodent handling, live animal surgery and collection of gastrointestinal tissue collection?
Do you have a PhD in Physiology, Biology or in a directly related field?
Documents Needed to Apply
University Of Arizona