659630 - Scientist II (Nci)

Leidos Frederick , MD 21705

Posted 4 months ago



The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.


The Scientist II will:

  • Lead medicinal chemistry efforts in a fast-paced work environment, providing chemistry support to the FNL/NCI RAS Initiative

  • Work closely with a highly collaborative multidisciplinary team of chemists, biochemists, structural and cell biologists, to develop and optimize pharmaceutical agents for use as RAS inhibitors

  • Design and synthesize pharmaceutically relevant small molecules for targets implicated in cancer

  • Conduct hit-to-lead chemistry efforts around targets identified as advanceable hits

  • Provide mentorship/supervision to Research Associate level chemists

  • Effectively communicate with Contract Research Organizations to further drug discovery efforts

  • Stay informed of the latest findings in cancer drug discovery and organic synthesis



To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a Doctorate degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency

  • In addition to the education requirement, a minimum of two (2) years of experience (post-PhD) in medicinal chemistry

  • Strong background in organic synthesis, including heterocyclic chemistry and covalent inhibitor design

  • Experience in disulfide tethering and fragment-based drug discovery

  • Expertise in the design, synthesis, and characterization of pharmaceutically relevant small molecules

  • Familiarity with modern analytical technologies including: LCMS, NMR (1H, 13C, 2D techniques), HPLC, IR, Flash chromatography

  • Must be highly collaborative, self-motivated, and team-oriented


Candidates with these desired skills will be given preferential consideration:

  • Experience of fragment screening library design

  • Mentoring/supervisory experience

  • Background in cancer drug discovery

  • Familiarity with common screening platforms used in cancer drug discovery

  • Able to balance workload over multiple projects

  • Excellent communication skills

  • Works well within a multidisciplinary team of Chemists, Biologists, Computational Chemists

Leidos Overview:

Leidos is a global science and technology solutions leader working to solve the world's toughest challenges in the defense, intelligence, homeland security, civil, and health markets. The company's 33,000 employees support vital missions for government and commercial customers. Headquartered in Reston, Virginia, Leidos reported pro forma annual revenues of approximately $10 billion for the fiscal year ended January 1, 2016 after giving effect to the recently completed combination of Leidos with Lockheed Martin's Information Systems & Global Solutions business (IS&GS). For more information, visit www.Leidos.com. The company's diverse employees support vital missions for government and commercial customers. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. Leidos will consider qualified applicants with criminal histories for employment in accordance with relevant Laws. Leidos is an equal opportunity employer/disability/vet.

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